三峡大学的研究人员敏锐地捕捉到了这一关键问题，开展了一项关于激活 sigma-1 受体在 DOX 诱导小鼠心脏毒性模型中作用的研究。他们旨在阐明 sigma-1 受体在这一过程中的作用机制，为解决 DOX 心脏毒性问题提供新的思路和方法。经过一系列严谨的实验研究，他们发现激活 sigma-1 受体能够显著改善心脏功能，减轻 DOX ...

为解决胰腺癌治疗难题，浙江大学医学院附属第一医院的研究人员开展了 MMP - 28 与胰腺癌关系的研究。结果发现 MMP - 28 可预测 EGFR 抑制剂疗效。这为胰腺癌治疗提供新思路，强烈推荐科研读者阅读。

Subsequently, DMM was induced in Lys-to-Arg (K48R and K63R) mutant ubiquitin (Ub) transgenic mice. Cytokine signalling in SW1353s was monitored by immunoblotting and novel ubiquitinated substrates ...

These useful findings assigned a novel functional implication of histone acylation, crotonylation. Although the mechanistic insights have been provided in great detail regarding the role of the YEATS2 ...

This valuable study reports on the critical role of ANKRD5 (ANKEF1) in sperm motility and male fertility. However, the supporting data remain incomplete. This work will be of interest to biomedical ...

If the goal is to detect specific associated proteins: Transfer the proteins from the SDS-polyacrylamide gel to a membrane and perform immunoblotting. If the goal is to determine the sizes and ...

Japan), and peritoneal thickness was measured using OLYMPUS cellSens Standard 2.1 (Olympus Co., Japan). 3.5 Canagliflozin inhibits fibrotic proteins expression in the peritoneal membrane of rats ...

润色专家意见:“…we detected TJ protein expression in injured spinal cord tissues from mice in the PBM group and SCI group by immunoblotting on post-SCI days 3, 7, and 14…” Please consider using the ...

γ-Secretase is a presenilin-containing intramembrane aspartyl protease complex that cleaves within the transmembrane domain (TMD) of nearly 150 substrates, with the amyloid precursor protein (APP) ...

During infection, pathogen sensing and cytokine signaling by the host induce expression of antimicrobial proteins and specialized post-translational modifications. One such protein is ISG15, a ...

Background and aims: Psychological stress plays an important role in an array of intestinal disorders. Corticotrophin releasing hormone (CRH) is involved in the pathogenic process induced by ...