This valuable study on strategies used by Pseudomonas to subvert hots immunity identifies a new immune evasion strategy. The study presents solid evidence on the cleavage of VgrG2B by Caspase 11 and ...

This means adults have a choice in which COVID vaccine they receive: an mRNA vaccine by Moderna or Pfizer, or Novavax, a protein-based vaccine that targets the virus in a more "traditional" way.

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. TLR8 senses single-stranded RNA (ssRNA) ...

Psoriasis is a multifactorial immune-mediated inflammatory disease. Its pathogenesis involves abnormal accumulation of neutrophils and T-cell related abnormalities. Pyroptosis is a type of regulated ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Despite severe cholestatic liver disease due ...

A team of researchers at the University of Pennsylvania took a new approach, using mRNA technology to design a multipronged vaccine that targets several proteins that underlie C. difficile’s ...

"We sought to explore if these attributes could be exploited to engineer highly stable and minimally toxic LNPs for mRNA delivery," the researchers report in the paper. By carefully testing ...

Credit: Novikov Aleksey / Shutterstock. US-based pharmaceutical company Moderna has dosed the first subject in the US in its Phase III Nova 301 clinical trial of its investigational norovirus vaccine, ...

Specifically, SPD’s binding to AhR plays a crucial role in modulating the inflammatory response and cellular pyroptosis by inhibiting both the AhR/NF-κB and NLRP3/caspase-1/GSDMD signaling pathways.

According to the complainant, the session’s title suggested a balanced presentation covering mRNA technologies in a pandemic scenario, but the content actually promoted Moderna’s Spikevax and ...