The conserved AAA-ATPase PCH-2 has been shown in several organisms including C. elegans to remodel classes of HORMAD proteins that act in meiotic pairing and recombination. In some organisms the ...

A definite conclusion would require at least 10 meioses, which is generally not the case. In this study, cosegregation of the variant with disease was only tested for 15 potentially pathogenic ...

Revised: This Reviewed Preprint has been revised by the authors in response to the previous round of peer review; the eLife assessment and the public reviews have been updated where necessary by the ...