Department of Computer Science, Purdue University, West Lafayette, Indiana 47907, United States Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, United States ...

Furin is identified as the key enzyme responsible for cleaving the apelin precursor. Inhibiting this cleavage could serve as ...

Most DUBs are Cys proteases; a small group are metalloproteases. DUBs are classified into five families (ubiquitin C-terminal hydrolases (UCHs), ubiquitin-specific proteases (USPs), Ovarian tumour ...

The Notch signaling pathway regulates important cellular processes involved in stem cell maintenance, proliferation, development, survival, and inflammation. These responses to Notch signaling ...

Sepsis is a deadly inflammatory syndrome caused by an exaggerated immune response to infection. Much has been focused on host response to pathogens mediated through the interaction of ...

Elevation of the proinflammatory cytokine Interleukin-1 (IL-1) is an integral part of the local tissue reaction to central nervous system (CNS) insult. The discovery of increased IL-1 levels in ...

All three SPG7 mutations lead to major abnormalities of the paraplegin protein. Paraplegin is a member of the mitochondrial metalloproteases, which are a subgroup of the AAA protein family. Other ...

This process relies on proteins such as matrix metalloproteases to 'chew' through the membrane. “We needed a new assay for invasion, that includes migration, to explain how normal cells invade ...

3 The Japan Agency for Medical Research and Development–Core Research for Evolutional Science and Technology (AMED–CREST), Japan Correspondence to Assistant Professor Satoshi Nojima, Department of ...

Our understanding of the relationship between the atheroprotective activities of HDL and heterogeneity of HDL particles has advanced greatly. HDL particles are highly heterogeneous in structure ...

Centre for New Antibacterial Strategies (CANS) and Research Group for Host-Microbe Interactions, Department of Medical Biology (IMB), UiT─The Arctic University of Norway, 9019 Tromsø, Norway ...

1 Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee, USA 2 Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA 3 Division of ...