These include the selective translation of mRNAs encoding proteins that are engaged in tumour cell proliferation, growth, angiogenesis, response to mitogenic stimuli and the tumour ...

The AP-1 transcription complex controls the expression of a subset of genes that are expressed early in response to extracellular mitogenic stimuli or to stress. It has been hypothesized that the ...

RNA-based therapeutics have rapidly emerged over the past decade, offering a new class of medicines that differ significantly from conventional drugs. These therapies can be programmed to target or ...

A common aspect of all forms of ACT is in vitro culture, where mitogenic stimuli and cytokines are used to develop a high number of tumor-reactive T cells for reinfusion. In contrast to liquid ...

Innate immunity is the first defense system against invading pathogens. Toll-like receptors (TLRs) are well-defined pattern recognition receptors responsible for pathogen recognition and induction of ...

1Division of Hematology/Oncology, University of California, San Francisco, San Francisco, California. 2Quantitative Biosciences Institute, University of California ...

Immunoglobulin G (IgG) antibodies are a critical component of the adaptive immune system, binding to and neutralizing pathogens and other foreign substances. Recent advances in molecular antibody ...

4 University of Giessen and Marburg Lung Center (UGMLC), member of the German Center of Lung Research (DZL), Giessen, Germany Until recently, three classes of medical therapy were available for the ...

Objective Serum α-fetoprotein (AFP) is the most commonly used biomarker for screening hepatocellular carcinoma (HCC) but fails to detect about half of the patients. Thus, we investigated if ...