The Company submitted an sNDA for ZORYVE foam for scalp and body psoriasis to the FDA based on the positive results from the pivotal ARRECTOR Phase 3 trial and a Phase 2b trial, which was accepted by ...

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1 Nitric oxide is a potent vasodilator, as it generates cyclic guanosine-5-monophosphate (cGMP). As cGMP is principally hydrolysed by phosphodiesterase-5 A (PDE-5 A), PDE-5 inhibitors potentiate the ...

Objective: To review available literature evaluating the pharmacology, pharmacokinetics, clinical efficacy, and adverse effects of cilomilast, a selective phosphodiesterase-4 (PDE4) inhibitor.

PDE2 (phosphodiesterase 2) is upregulated in human heart failure. Cardiac PDE2‐transgenic mice are protected against contractile dysfunction and arrhythmias in heart failure but whether an acute ...

Adults with progressive pulmonary fibrosis met the primary endpoint of absolute change in FVC with 52-week oral nerandomilast ...

Viagra improves erections in over 80% of men taking 100 mg, it takes an average of 36 minutes to work, with effects lasting ...

Nerandomilast, an oral phosphodiesterase 4B inhibitor, hit the primary endpoint in a Phase III trial in progressive pulmonary ...

Dermatologists are practicing in an “era of good efficacy” of nonsteroidal topical therapies for psoriasis, and they can help patients access newer topical medications by working with pharmacies that ...

Medications to treat ED are exceedingly popular, with sildenafil (sold under the more commonly known brand name Viagra) being ...

Orismilast may be an effective and safe novel treatment option for adult patients with moderate to severe atopic dermatitis.

Researchers were originally studying sildenafil as a potential treatment for high blood pressure. However, during clinical ...