CYP is an alkylating prodrug with antineoplastic and immunosuppressive properties. CYP is converted in the liver into two active metabolites, phosphoramide mustard and aldophosphamide, which ...

In the liver, cyclophosphamide is converted to the active metabolites aldophosphamide and phosphoramide mustard, which bind to DNA, thereby inhibiting DNA replication and initiating cell death.

Department of Chemistry, Faculty of Science (Boys), Al-Azhar University, 11884 Nasr City, Cairo, Egypt ...