Proper activation of STING signaling requires STING translocation and phosphorylation. Here, we show that dual serine/threonine and tyrosine protein kinase (DSTYK) directly phosphorylates STING Ser366 ...

This month's cover highlights the article RudLOV is an optically synchronized cargo transport method revealing unexpected effects of dynasore by Akiko K. Satoh, Takunori Satoh and colleagues. The ...

Adrenomedullin (ADM) inhibits endothelial insulin signaling, contributing to obesity-associated insulin resistance, according to research conducted by the Max Planck Institute for Heart and Lung ...

Harada et al. 3 have now identified PKA as the kinase that phosphorylates serine 112 of BAD. They did this by purifying the kinase activity, which was present principally in heavy membrane ...

Haspin phosphorylates histone H3 threonine 3 (H3T3) to ensure proper progression through mitosis. Here the authors describe how Haspin engages a nucleosomal DNA supergroove, using electrostatic ...

Researchers identified an enzyme that helps Plasmodium-infected red blood cells adhere to the placenta, providing molecular ...

The preliminary data presented in this manuscript seem valuable. The data are currently incomplete and there are numerous technical concerns, some of which may arise from insufficient description of ...

为解决 SSP 在 DILI 中调控机制不明的问题，中国科学院上海生物化学与细胞生物学研究所的研究人员开展相关研究，发现 MAPK13 影响 PHGDH 降解加重肝损伤，抑制 MAPK13 或补充丝氨酸可缓解。推荐科研读者阅读，助力相关研究。

This important manuscript proposes a new strategy for the identification of new mechanisms of drug resistance based on SAturated Transposon Analysis in Yeast (SATAY), a powerful transposon sequencing ...

ATG7, one of the core proteins of autophagy, plays an important role in various biological processes, including the regulation of autophagy. While clear that autophagy drives angiogenesis, the role of ...

Alpha-arbutin (4-hydroxyphenyl alpha-glucopyranoside) is a known inhibitor of tyrosinase in keratinocytes; however, its effect on other genes and pathways in other skin cells has not been thoroughly ...