In studying GBP1 in uninfected cells, we have found that an IFNy-induced kinase, PIM1, phosphorylates GBP1 driving it towards its locked state bound to a cellular scaffold protein. PIM1 is an ...

They may be part of signal transduction cascades in which one kinase phosphorylates one kinase (making it a phosphoprotein) or multiple kinases, to amplify and propagate a cellular signal.

Pef1 and PP4 control the phosphorylation state of the cohesin kleisin Rad21. The CDK phosphorylates Rad21 on Threonine 262. Pef1 ablation, non-phosphorylatable Rad21-T262 or mutations within a Rad21 ...

The immune system has ‘T’ cells that recognize when the body is infected with a virus or bacterium and mount an immune response that is targeted to that microbe. They can also find and eliminate ...