Conclusions Our findings highlighted that KLHL21 loss triggers STAT3 reactivation through PABPC1-mediated PIK3CB translational activation, and targeting STAT3 can reverse preneoplastic metaplasia in ...

Stomach diseases are any diseases that affect the normal functioning of the stomach. Stomach diseases include stomach cancer, gastritis, peptic ulcers, gastroparesis. Many stomach diseases are ...

These pathways are activated by both cytoplasmic dsDNA inside the preneoplastic cells and tumor DNA engulfed by APCs. The downstream of type I IFN is the cross-priming of immune cells, such as NK ...

Objective Tumour heterogeneity represents a major obstacle to accurate diagnosis and treatment in gastric adenocarcinoma (GA). Here, we report a systematic transcriptional atlas to delineate molecular ...

The high mobility group A (HMGA) family is composed of four proteins, HMGA1a, HMGA1b, HMGA1c and HMGA2, encoded by two distinct genes. HMGA1 proteins are products of the same gene, generated ...

Nonalcoholic fatty liver disease (NAFLD) includes a series of hepatic manifestations, starting with liver steatosis and potentially evolving towards nonalcoholic steatohepatitis (NASH), fibrosis, ...

1Sylvester Comprehensive Cancer Center, Miller School of Medicine at the University of Miami, Miami, Florida. Search for other works by this author on: 1Sylvester Comprehensive Cancer Center, Miller ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Basal-like breast cancers exhibit distinct ...

aDepartment of Neurosciences, Alzheimer Research Laboratory, School of Medicine, Case Western Reserve University, Cleveland, OH, USA Peroxisome proliferator-activated receptors (PPAR) are members of a ...