Dehydrolactone (middle panel) in a polypeptide undergoes an intermolecular rearrangement to generate a ketide with a new carbon-carbon bond in the backbone. The researchers installed dehydrolactone in ...

Advances in protein sequencing enable deeper insights and facilitate applications such as biomarker discovery and ...

Two recent AI methods, RFdiffusion and ProteinMPNN, have totally changed the nature of biotherapeutics discovery.

All biological function is dependent on how different proteins interact with each other. Protein-protein interactions ...

Deep generative models that learn from the distribution of natural protein sequences and structures may enable the design of new proteins with valuable functions. While the majority of today’s models ...

Ribonucleic acid, commonly known as RNA, is involved in many biological functions, and some, including gene silencing, are ...

(3,4) These proteins are generally classified into two categories based on their ability to bind DNA or RNA, although many NABPs can bind both exhibiting sequence and structural specificities.

GMP Human FGF-8b Protein (Cat. No. GMP-FGBH16) and Human FGF-8b Protein, Premium Grade (Cat. No. FGB-H5115) exhibit similar ...

Medicine often takes a one-size-fits-all approach, but a disorder's root cause can vary. Vanderbilt researchers have found ...

Ribonucleic acid, commonly known as RNA, is involved in many biological functions, and some, including gene silencing, are utilized to cure diseases. RNA has recently gained attention as a promising ...

Synthetic proteins that promote multi-step catalysis have previously proven challenging to engineer. But the team behind this ...

This study presents an important discovery regarding the diversity and evolution of gall-forming microbial effectors. Supported by convincing computational structural predictions and analyses, the ...