This P improved trimer integrity compared to I559P in selected properties. Next, we screened 15 structure-guided potential cysteine pairs in gp140 and found that A501C-L663C (“CC2”) forms an ...

Eli Lilly bought a stake in Protomer Technologies and its glucose-sensing insulin platform last year, and it must like what it has seen in the programme since then – it has just agreed to buy ...

近日，上海大学医学院卞月珉教授与美国哈佛大学医学院Jonathan Abraham教授团队、波士顿大学医学院Rachel Fearns教授团队合作，作为共同作者，在国际顶级期刊《Cell》上发表题为Structural and functional ...

Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, New South Wales 2522, Australia ...

Departments of Mathematics, University of York, York YO10 5DD, U.K. Departments of Mathematics, University of York, York YO10 5DD, U.K. Department of Biology ...

After its discovery in 1994, leptin became the great hope as an anti-obesity treatment based on its ability to reduce food intake and increase energy expenditure. However, treating obese people with ...

This manuscript describes a fundamental investigation of the functioning of Cas9 and in particular on how variant xCas9 expands DNA targeting ability by an increase-flexibility mechanism. The authors ...