Furthermore, extracellular microRNA has been shown to be involved in communication between various cell types. Importantly, the exRNA is protected from RNases degradation by certain carriers including ...

The extracellular barriers include the cell membrane, ion pumps and channels, and the presence of RNases in skin and blood, among other issues. The intracellular barriers include endosomal escape ...

In human beings, there is a ∼16,569 bp circular mitochondrial DNA (mtDNA) encoding 22 tRNAs, 12S and 16S rRNAs, 13 polypeptides that constitute the central core of ETC/OxPhos complexes, and some ...

然而，传统 RNAi 疗法使用的反义寡核苷酸和小干扰 RNA（siRNAs）存在诸多问题，如细胞摄取差、递送效率低、潜在系统毒性以及易被血清核糖核酸酶（RNases）降解等 。核糖核酸酶靶向嵌合体（RiboTACs）技术的出现为 RNAi 带来新希望，它能通过招募 RNase L 选择性降解 ...