They have a tough game in Buffalo on Sunday night. A loss would further complicate their path to the postseason.So how is ...

Christian McCaffrey rarely has been taken off the field since returning from an eight-game absence due to bilateral Achilles ...

"We're just going to keep chopping wood," said running back Christian McCaffrey, as more 49ers stars grapple with ...

The San Francisco 49ers are preparing for their Week 13 contest against the Buffalo Bills on Sunday at Highmark Stadium in ...

Deebo Samuel probably is the most disappointing player on the most disappointing team in the NFL through 12 weeks. Here's ...

The early portion of Wednesday's practice produced no encouraging signs for 49ers quarterback Brock Purdy. Brandon Allen, ...

Bad news for the 49ers. Brock Purdy still isn't ready to resume throwing. Technically, he threw one pass on Wednesday -- a ...

The San Francisco 49ers have officially opened linebacker Dre Greenlaw's 21-day practice window, giving the team until ...

The San Francisco 49ers are preparing for their Week 13 contest against the Buffalo Bills on Sunday at Highmark Stadium in ...

Through the first four weeks of the season, Fred Warner was the front-runner to win the Defensive Player of the Year Award.

Brock Purdy (right shoulder) will have a limited practice Wednesday, coach Kyle Shanahan said.Purdy, though, might not throw.

The 49ers are welcoming Brock Purdy back to practice today after shoulder soreness kept him out of Sunday's loss at ...