Synonymous mutations can also influence the speed of translation because the precise codon used determines how quickly it’s translated by ribosomes. For instance, one 2016 study reported that a ...

However, just because these codons encode the same amino acid, it doesn’t mean they don’t have distinct effects on cellular efficiency. A certain synonymous codon can be optimal and efficient in one ...

was recoded with 631 synonymous mutations to give a codon pair bias ∼4.5-fold lower than that of wild-type poliovirus. The attenuated virus was further manipulated by recombining segments of ...

BIOPHYSICAL JOURNAL 114. (2018): 1009-1017. Print. * G.A., Babbitt, et al. "Triplet codon organization optimizes the impact of synonymous mutation on nucleic acid molecular dynamics." JOURNAL OF ...