The life cycle of viruses varies greatly depending on the type and class of virus, but they follow the same basic stages of viral replication, i.e., adsorption, entry, uncoating, replication, assembly ...

Adeno-associated viruses (AAV) have emerged as the lead vector in clinical trials and form the basis for several approved gene therapies for human diseases, mainly owing to their ability to sustain ...

These results indicate that OCRL acts as an uncoating factor and that defects in clathrin-mediated endocytosis likely contribute to pathology in patients with OCRL mutations. Oculo-Cerebro-Renal ...