CLDN1 Gene - GeneCards | CLD1 Protein | CLD1 Antibody
2024年10月1日 · CLDN1 (Claudin 1) is a Protein Coding gene. Diseases associated with CLDN1 include Ichthyosis, Leukocyte Vacuoles, Alopecia, And Sclerosing Cholangitis and Sclerosing Cholangitis. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling and Cell junction organization.
Claudin-1-targeted therapies break barriers in precision oncology
Targeting exposed CLDN1 on tumours could help kill cancer cells and break down the collagen barrier, improving access for immune cells and immunotherapies.
Profibrotic protein Claudin-1 - Science | AAAS
2022年12月21日 · Corroborating a pathogenetic role of CLDN1 for liver fibrosis, CLDN1 is the most highly expressed CLDN family member in fibrotic liver (fig. S1A) and the only family member significantly up-regulated in fibrosis (P < 0.0001; fig. S1B).
CLDN1 claudin 1 [Homo sapiens (human)] - Gene - NCBI
2024年11月2日 · Title: CLDN1 Arg81His founder variant causes ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis (ILVASC) syndrome in Moroccan Jews. Claudin-1 interacts with EPHA2 to promote cancer stemness and chemoresistance in colorectal cancer.
9076 - Gene ResultCLDN1 claudin 1 [ (human)] - National Center …
CLDN1 is a biomarker for intestinal-type gastric cancer with shorter survival. The expression of CLDN1 was strongly associated with beta-catenin in gastric cancer patients and a gastric cancer cell model. The forced expression of CLDN1 restored HCV entry. Low CLDN1 expression is associated with adamantinomatous Craniopharyngioma.
Claudin-1 induces epithelial–mesenchymal transition through activation ...
2012年11月19日 · In this study, we show that CLDN1 has a causal role in the epithelial–mesenchymal transition (EMT) in human liver cells, and that the c-Abl-Ras-Raf-1-ERK1/2 signaling axis is critical for the...
Claudin-1 is a hepatitis C virus co-receptor required for a ... - Nature
2007年2月25日 · CLDN1 is required for HCV infection of human hepatoma cell lines and is the first factor to confer susceptibility to HCV when ectopically expressed in non-hepatic cells.
Frontiers | The role and mechanism of claudins in cancer
2022年12月21日 · CLDN1 is one of the most-studied CLDNs in cancer (Figure 1). CLDN1 promotes the growth and progression of various tumors, including breast cancer, melanoma, oral squamous cell carcinoma, thyroid cancer, ovarian cancer, colon cancer, gastric cancer, hepatocellular carcinoma, and pancreatic cancer.
Claudin-1 (CLDN1) is a cell membrane protein mediating cell adhesion, signaling and epithelial-mesenchymal differentiation (EMT). Furthermore, CLDN1 is a cell entry factor and signal transducer of hepatitis C virus, a major cause of liver fibrosis and HCC worldwide.
CLDN1 Sensitizes Triple-Negative Breast Cancer Cells to …
2022年10月14日 · About 77% of the TNBC displays a lack of claudin-1 (CLDN1), a major tight junction component. We demonstrated that CLDN1 increased the sensitivity of TNBC cell lines to the main chemotherapeutic agents commonly used for breast cancer treatment.
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