FGF/FGFR signaling in health and disease | Signal Transduction …
2020年9月2日 · Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR) signaling has crucial roles in a multitude of processes during embryonic …
The Fibroblast Growth Factor signaling pathway - PMC
FGFRL1, with structural similarity to FGFRs, is a membrane protein of ∼500 amino acids with three extracellular immunoglobulin-like domains (I, II, and III), a transmembrane domain (TM), …
Pharmacological and Biological Targeting of FGFR1 in Cancer
2024年11月18日 · This review will outline the structural features of FGFR1 and its signaling pathways, delineate the roles of different FGFR1 mutation types in tumorigenesis, and discuss …
Differential regulation of fibroblast growth factor receptor 1 ...
2019年6月17日 · Galectin-1 mimics fibroblast growth factor as it efficiently activates FGFR1 and receptor-downstream signaling pathways that result in cell proliferation and apoptotic evasion. …
N-glycosylation acts as a switch for FGFR1 trafficking between the ...
2023年7月21日 · Collectively, our data define N-glycosylation of FGFR1 as an important regulator of FGFR1 kinase activity and, most importantly, as a switchable signal for FGFR1 trafficking …
Diverse Fgfr1 signaling pathways and endocytic trafficking …
2024年2月16日 · The Fibroblast growth factor (FGF) pathway is a conserved signaling pathway required for embryonic development. Activated FGF receptor 1 (FGFR1) drives multiple …
Role of FGF/FGFR signaling in skeletal development and ... - Nature
2014年4月29日 · Fibroblast growth factor (FGF)/fibroblast growth factor receptor (FGFR) signaling plays essential roles in bone development and diseases. Missense mutations in FGFs and …
Fibroblast growth receptor 1 is regulated by G-quadruplex in
2024年8月9日 · Additionally, FGFR1 signaling can stabilize Twist, an EMT-related transcription factor, and propagate drug-persistent, mesenchymal subpopulations 7. Previous findings by …
The FGFR1 Signaling Pathway Upregulates the Oncogenic …
2023年1月1日 · In summary, we demonstrated that activation of the FGFR1 signaling robustly upregulates FOXQ1 expression through activating FGFR1-MEK-ERK2 to upregulate c-FOS …
Fibroblast growth factor (FGF) signaling in development and …
2014年12月1日 · FGF signaling generally follows one of three transduction pathways: RAS/MAP kinase, PI3/AKT, or PLCγ. Each pathway likely regulates specific cellular behaviors. …