【4.1.2】RNA的三级结构（pseudoknot，kissing loop） - Sam' …
2018年8月30日 · kissing loop An example of an RNA stem-loop. If now a second RNA stem-loop has complementary base-sequence, the two loops can base pair resulting in a kissing loop.
Kissing stem-loop - Wikipedia
In genetics, a kissing stem-loop, or kissing stem loop interaction, is formed in ribonucleic acid (RNA) when two bases between two hairpin loops pair. These intra- and intermolecular kissing interactions are important in forming the tertiary or quaternary structure of many RNAs.
Thermodynamic and Kinetic Analysis of an RNA Kissing …
2012年3月7日 · Kissing hairpin interactions form when the loop residues of two hairpins have Watson-Crick complementarity. In a unimolecular context, kissing interactions are important for tertiary folding and pseudoknot formation, whereas in a bimolecular context, they provide a basis for molecular recognition.
RCSB PDB - 1KIS: TAR-TAR "KISSING" HAIRPIN COMPLEX …
1997年6月11日 · Kissing hairpins are important in natural antisense reactions; their complex is a specific target for protein binding. The complex has all six nucleotides of each loop paired to form a bent quasicontinuous helix of three coaxially stacked helices: two stems plus a loop-loop interaction helix.
The structure of an RNA “kissing” hairpin complex of the HIV …
1997年5月30日 · We have used nuclear magnetic resonance (NMR) to obtain the structure of an RNA “kissing” hairpin complex formed between the HIV-2 TAR hairpin loop and a hairpin with a complementary loop sequence. Kissing hairpins are important in natural antisense reactions; their complex is a specific target for protein binding. The complex has all six ...
Mutations in the kissing-loop hairpin of human …
A stem-loop termed the kissing-loop hairpin is one of the most highly conserved structures within the leader of human immunodeficiency virus type 1 (HIV-1) and chimpanzee immunodeficiency virus genomic RNA. Because it plays a key role in the in vitro dimerization of short HIV-1 RNA transcripts (M. L …
Structure and stability of RNA/RNA kissing complex: with …
2011年2月10日 · In particular, we consider two types of kissing interactions (see Fig. 3A,B): kissing contact between hairpin loops (Fig. 3A) and between a hairpin loop and a dangling tail (Fig. 3B). For structures shown in Figure 3, the phantom linker (filled circles) resides inside the region from a to b and thus is a type-1 structure.
HIV-1 Genome Dimerization: Kissing-Loop Hairpin Dictates …
1997年8月5日 · Adjacent genomic RNAs from human immunodeficiency virus type 1 (HIV-1) can form loose or tight dimers depending on whether their respective kissing-loop hairpins (nts 248−270 in HIV-1 Lai) bond via their autocomplementary sequences (ACS) or via the ACS and stem sequences [Laughrea, M., & Jetté, L. (1996a) Biochemistry 35, 1589−1598].
Thermodynamic investigation of kissing-loop interactions
2019年2月1日 · To assess the effect of kissing on the stems, we investigated first the kissing hairpins individually, KHp1 and KHp2, and then the T-loop kissing hairpin, TLKHp2. We also assessed the thermodynamics of bimolecular kissing interactions by mixing KHp1 and KHp2, as well as mixing the kissing sequences alone, KS1 and KS2.
Thermodynamic and Kinetic Analysis of an RNA Kissing ... - Cell …
2012年3月7日 · In some cases, kissing complexes can be a prelude to strand displacement reactions where the two hairpins resolve to form a stable extended intermolecular duplex. The kinetics and thermodynamics of kissing-complex formation and their subsequent strand-displacement reactions are poorly understood.