mTOR - Wikipedia
The mammalian target of rapamycin (mTOR), [5] also referred to as the mechanistic target of rapamycin, and sometimes called FK506-binding protein 12-rapamycin-associated protein 1 (FRAP1), is a kinase that in humans is encoded by the MTOR gene.
Targeting the biology of aging with mTOR inhibitors - Nature
2023年5月4日 · Inhibition of the protein kinase mechanistic target of rapamycin (mTOR) with the Food and Drug Administration (FDA)-approved therapeutic rapamycin promotes health and longevity in diverse model...
Rapamycin: one drug, many effects - PMC - PubMed Central (PMC)
The mammalian target of rapamycin (mTOR) signaling pathway is a master regulator of cell growth and metabolism. Deregulation of the mTOR pathway has been implicated in a number of human diseases such as cancer, diabetes, obesity, neurological diseases and genetic disorders.
Multifaceted role of mTOR (mammalian target of rapamycin) …
2023年10月2日 · The mammalian target of rapamycin (mTOR) is a protein kinase that controls cellular metabolism, catabolism, immune responses, autophagy, survival, proliferation, and migration, to maintain ...
Inhibition of the Mechanistic Target of Rapamycin (mTOR)–Rapamycin …
In this article, we discuss the molecular biology of mTOR, research into the mechanism by which mTOR inhibition promotes life span, the side effects of rapamycin, and possible ways in which rapamycin or alternative strategies to inhibit mTOR signaling may enable us to extend human life span and health span.
mTOR Signaling in Growth, Metabolism, and Disease - PMC
Despite these insights, the full mechanism of action of rapamycin remained elusive until 1994 when biochemical studies identified the mechanistic (formerly “mammalian”) Target of Rapamycin (mTOR) as the direct target of the rapamycin-FKBP12 complex in mammals (Brown et. al. 1994; Sabatini et. al. 1994; Sabers et. al 1995), and revealed it ...
Targeting ageing with rapamycin and its derivatives in humans: a ...
This finding suggests that even though the pharmacokinetics of rapamycin are well known, pharmacodynamic studies that focus on target (ie, mTOR) engagement and the effects of rapamycin on ageing-related biomarkers are needed to …
Rapamycin passes the torch: a new generation of mTOR …
2011年10月31日 · Mammalian target of rapamycin (mTOR) is an atypical protein kinase that controls growth and metabolism in response to nutrients, growth factors and cellular energy levels, and it is frequently...
mTOR Signaling in Growth, Metabolism, and Disease - Cell Press
The mechanistic target of rapamycin (mTOR) coordinates eukaryotic cell growth and metabolism with environmental inputs, including nutrients and growth factors.
Multifaceted role of mTOR (mammalian target of rapamycin) …
2023年10月2日 · The mammalian target of rapamycin (mTOR) is a protein kinase that controls cellular metabolism, catabolism, immune responses, autophagy, survival, proliferation, and migration, to maintain cellular homeostasis.