Imidazobenzodiazepines - an overview | ScienceDirect Topics
2012年3月3日 · Imidazole-fused benzodiazepines are prominent pharmacophores proved to be potent central nervous system (CNS) depressants in several marketed drugs such as …
Chemical structure and properties of midazolam compared with …
2 Some properties of midazolam that are of special interest for its practical use are discussed, such as: the basicity of its imidazole ring nitrogen, which allows water-soluble salts and well …
Imidazobenzodiazepines - an overview | ScienceDirect Topics
Imidazobenzodiazepines are a type of benzodiazepine site ligands that interact with specific receptor subtypes in the brain, such as α4βγ2 or α6βγ2 receptors, and are used for …
Benzodiazepines | Anesthesiology Core Review: Part One Basic …
The most common intravenous benzodiazepines administered in the perioperative setting are midazolam, diazepam, and lorazepam. Benzodiazepines produce hypnosis, sedation, …
Midazolam (Versed, Roche, U.S.A.; Dormicum, Roche, other countries; Ro 21 -3981) is the first ben- zodiazepine derivative with water-soluble salts. It represents an advance in drug efficacy …
1,4-Benzodiazepines: Chemical stability and ... - ScienceDirect
2021年12月1日 · The incorporation of imidazole or triazole at 1, 2 position of benzodiazepine can increase the stability of the drug such as alprazolam, midazolam and estazolam [9]. Different …
Benzodiazepines - SpringerLink
2020年8月14日 · Currently, approximately 24 benzodiazepines, including prodrugs, are approved for use in the United States and are prescribed as anxiolytics, muscle relaxants, anesthetic …
Chromatographic separation of the interconverting enantiomers of ...
2021年6月21日 · A structural variation of the classical benzodiazepine skeleton is observed e.g. in alprazolam, midazolam, and related benzodiazepines, which contain a 1,2,4-triazole or an …
Unexpected transformation of 1,5-benzodiazepine derivatives …
2023年6月24日 · In an attempt to synthesize new derivatives of imidazo[1,5-a][1,5]benzodiazepine-3-carboxylic acid esters by activation of the amide group of the …
Synthesis and evaluation of imidazo[1,5-a][1,4]benzodiazepine …
1993年4月1日 · Quantitative Structure–Activity Relationship Studies for the Binding Affinities of Imidazobenzodiazepines for the α6 Benzodiazepine Receptor Isoform Utilizing Optimized …
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