The role of PINK1–Parkin in mitochondrial quality control
2024年10月2日 · Mitophagy mediated by the recessive Parkinson’s disease genes PINK1 and Parkin responds to mitochondrial damage to preserve mitochondrial function. In the pathway, PINK1 is the damage sensor,...
线粒体自噬通路 (Mitophagy pathway) - Abcam中文官网
线粒体自噬是指通过自噬体选择性地去除受损线粒体，随后通过溶酶体对其进行分解代谢。 通过我们的交互通路了解 PINK1、Parkin 和自噬机制在线粒体自噬通路中的作用，并阅读包含 Abcam 完整产品的弹出窗口和产品列表，确定可促进您研究的关键试剂。 点击下载线粒体自噬交互通路海报。 目录. 线粒体自噬通路：概述. 线粒体自噬是一种重要的线粒体质量控制机制，可去除受损的线粒体。 哺乳动物的线粒体自噬通路涉及 PTEN 诱导的假定蛋白激酶 1 (PINK1) 和 E3 泛素连接 …
Parkin regulates adiposity by coordinating mitophagy with …
2022年11月4日 · Taken together, our findings indicate that Parkin regulates mitochondrial homeostasis by balancing mitophagy and Pgc1α-mediated mitochondrial biogenesis in white adipocytes, suggesting a...
Mechanisms of mitophagy in cellular homeostasis, physiology …
2018年8月28日 · Emerging findings suggest a causative relationship between PINK1 kinase activity and Parkin stimulation during mitochondrial damage. PINK1-dependent phosphorylation alters Parkin conformation,...
Mitophagy pathway overview: PINK1, Parkin, autophagy | Abcam
2021年5月16日 · In mammals, the mitophagy pathway involves PTEN-induced putative protein kinase 1 (PINK1) and the E3 ubiquitin ligase Parkin. Learn the role of PINK1, Parkin, and the autophagy machinery in the mitophagy pathway with our interactive pathways and identify key reagents to further your research by reading the pop ups and product tables that ...
Mitochondrial degradation: Mitophagy and beyond - Cell Press
2023年9月13日 · The reason behind the interest in characterizing PINK1 and Parkin is due to their involvement in familial forms of Parkinson’s disease. 20,21 PINK1/Parkin mitophagy is predominantly activated in response to mitochondrial stress 19 and therefore should be largely viewed as a damage response pathway.
PINK1 and Parkin mitochondrial quality control: a source of …
2020年3月13日 · In this review, we focus on understanding the unique challenges faced by the mitochondria in neurons vulnerable to neurodegeneration in Parkinson’s and summarize evidence that mitochondrial dysfunction contributes to disease pathogenesis and …
Mitophagy: Molecular Mechanisms, New Concepts on Parkin
2021年12月23日 · The best-characterized mitophagy pathway is the PTEN-induced putative kinase 1 (PINK1)/Parkin-dependent pathway. However, other Parkin-independent pathways are also reported to mediate the tethering of mitochondria to the autophagy apparatuses, directly activating mitophagy (mitophagy receptors and other E3 ligases).
Parkin coordinates mitochondrial lipid remodeling to execute mitophagy …
2022年12月6日 · Mitochondrial Parkin induces the production of phosphatidic acid (PA) and its subsequent conversion to diacylglycerol (DAG) by recruiting phospholipase D2 and activating the PA phosphatase, Lipin-1. The production of DAG requires mitochondrial ubiquitination and ubiquitin-binding autophagy receptors, NDP52 and optineurin (OPTN).
Investigation of USP30 inhibition to enhance Parkin-mediated mitophagy …
The Parkin +/+, Parkin +/R275W and Parkin R275W/R275Q fibroblasts were treated with the indicated concentrations of USP30Inh-1 for (C) 6 h or (D) 6 days before inducing mitophagy with 10 µM FCCP for 2 h. The immunoreactivity of p-Ser65-Ub was quantified from three independent experiments for each condition.
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