- Mechanistic target of rapamycinRapamycin works by suppressing a signaling enzyme known as mTOR (short for mechanistic target of rapamycin), which is a fundamental decision maker for most cells in the body and brain.www.nationalgeographic.com/science/article/rapamycin-anti-aging-longevity
Rapamycin administration causes a decrease in muscle contractile ...
1 天前 · Emerging evidence suggests the potential of rapamycin, an antibiotic from Streptomyces hygroscopicus that functions as a mechanistic target of rapamycin (mTOR) inhibitor, as a …
Here’s what you need to know about the drug linked to living longer
2 天之前 · Rapamycin (red) inhibits a protein complex called mTORC1 (mammalian target of rapamycin complex 1, blue). It is mainly used to prevent rejection in organ transplantation, but …
Mtor Inhibition Alleviated Tau Phosphorylation-Induced ... - SSRN
2 天之前 · Whether mammalian target of rapamycin (mTOR) directly interacts with the Tau protein at Ser214, Ser356 and Thr231 is not clear. This study aimed to investigate whether mTOR …
抑制与降解相结合的双靶双机制设计策略—小柯机器人—科学网
2 天之前 · 雷帕霉素（mtor）和g1至s期转换1基因（gspt1）的哺乳动物靶点在胶质母细胞瘤中过表达，调节重要的细胞功能。 目前的mTOR抑制剂在临床疗效和耐药性 ...
Rapamycin improves sociability in the BTBR T + Itpr3tf /J mouse …
3 天之前 · Recent data support a role for the mammalian target of rapamycin (mTOR) signaling pathway in the pathogenesis of impaired sociability in ASD (Crino, 2011).
Targeting hypoxia inducible factor-1 alpha in rheumatoid arthritis ...
1 天前 · Activation of mechanistic target of rapamycin (mTOR) downstream of complement 3a receptor (C3aR), dectin-1 C-type lectin receptor, and cytokines, drives HIF-1α protein …
SMRT-depleted conventional DCs maintain inflammation despite …
2 天之前 · Ohtani, M. et al. Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells. …
A Dual-Target and Dual-Mechanism Design Strategy by …
4 天之前 · Glioblastoma, a highly aggressive brain tumor, lacks effective treatment with low 5 year survival rates. Urgency for new therapies is evident. Mammalian targets of rapamycin (mTOR) …
CD97 maintains tumorigenicity of glioblastoma stem cells via …
2 天之前 · mTOR is an intracellular serine/threonine conserved protein kinase in two distinct complexes, mTORC1 and mTORC2. mTORC1, which is rapamycin sensitive, controls cell …
Aging Lung: Molecular Drivers and Impact on Respiratory …
4 天之前 · The activation of the mammalian target of rapamycin (mTOR), which regulates many biological processes in aging, inhibits SIRT1 in individuals exposed to smoke, thereby …
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