Role of FGF/FGFR signaling in skeletal development and ... - Nature
2014年4月29日 · Multiple kinds of mouse models, mimicking human skeleton diseases caused by missense mutations in FGFs and FGFRs, have been established by knock-in/out and transgenic technologies. These...
Role of Fibroblast Growth Factor Receptor 2 (FGFR2) in Corneal
2023年9月1日 · Purpose: To determine the role of fibroblast growth factor receptor 2 (FGFR2)-mediated signaling in keratocytes during corneal development, a keratocyte-specific FGFR2-knockout (named FGFR2cKO) mouse model was generated, and its phenotypic characteristics were determined.
OTUB1 promotes osteoblastic bone formation through stabilizing FGFR2
2023年4月7日 · Here, we show that the global and conditional osteoblast knockout of a deubiquitinase Otub1 result in low bone mass and poor bone strength due to defects in osteogenic differentiation and...
Neonatal loss of FGFR2 in astroglial cells affects locomotion ...
2023年3月11日 · We examined three different sets of mice that had a cell type-targeted knock-out of FGFR2: 1) knockout during embryogenesis, in radial glial cells and therefore both their neuronal and...
Role of Fibroblast Growth Factor Receptor 2 (FGFR2) in Corneal …
Purpose: To determine the role of fibroblast growth factor receptor 2 (FGFR2)–mediated signaling in keratocytes during corneal development, a keratocyte-specific FGFR2-knockout (named FGFR2cKO) mouse model was generated, and its phenotypic characteristics were determined.
Mouse genetics identifies unique and overlapping functions of ...
Here, we show that FGFR3 in keratinocytes is dispensable for mouse skin development, homeostasis and wound repair. However, the defect in the epidermal barrier and the resulting inflammatory skin disease that develops in mice lacking FGFR1 and FGFR2 in keratinocytes were further aggravated upon additional loss of FGFR3.
Conditional knockdown of Fgfr2 in mice using Cre-LoxP induced …
2005年1月1日 · In this study, we were able to generate the U6-ploxPneo-Fgfr2 mice in 3 months, a significant gain of time compared with homologous recombination procedures for the conditional gene knockouts (12–24 months). Moreover, because RNAi acts dominantly, only one allele of transgene is needed to suppress the endogenous genes, and it reduces the time ...
Fgfr2 fibroblast growth factor receptor 2 [ (house mouse)]
2024年8月21日 · Neonatal loss of FGFR2 in astroglial cells affects locomotion, sociability, working memory, and glia-neuron interactions in mice. Somatic FGFR2 is Required for Germ Cell Maintenance in the Mouse Ovary. Paracrine interactions through FGFR1 and FGFR2 receptors regulate the development of preimplantation mouse chimaeric embryo.
Fgfr2 is required for the development of the medial prefrontal …
2010年4月21日 · To understand the role of specific fibroblast growth factor receptors (FGFRs) in cortical development, we conditionally inactivated Fgfr2 or both Fgfr1 and Fgfr2 [Fgfr2 conditional knock-out (cKO) or double knock-out mice, respectively] in radial glial cells of …
Fgfr2 Knockout (Fgfr2tm1Cxd) Mouse Model for Developmental …
2012年4月19日 · FGFR2 knockout is an embryonic lethal mutation and blocks limb bud initiation. Fibroblast Growth Factor Receptor 2 (FGFR2) is a high affinity receptor for several members of the FGF family. The FGFR2 gene was inactivated by deleting the entire immunoglobulin-like domain of the receptor which is critical for FGF binding and FGFR2 activity.
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