Histone - Wikipedia
Schematic representation of the assembly of the core histones into the nucleosome. In biology, histones are highly basic proteins abundant in lysine and arginine residues that are found in eukaryotic cell nuclei and in most Archaeal phyla.
Histone - National Human Genome Research Institute
2 天之前 · A histone is a protein that provides structural support for a chromosome. Each chromosome contains a long molecule of DNA, which must fit into the cell nucleus. To do that, the DNA wraps around complexes of histone proteins, giving the chromosome a more compact shape. Histones also play a role in the regulation of gene expression.
A vector system encoding histone H3 mutants facilitates ... - Nature
2 天之前 · Histone H3 K-to-M mutations function as dominant negative molecules by repressing the activity of the histone methyltransferases targeting a specific lysine residue on the endogenous histone H3 ...
Histone lysine methylation modifiers controlled by protein stability
2024年10月11日 · Histone lysine methylation is pivotal in shaping the epigenetic landscape and is linked to cell physiology. Coordination of the activities of multiple histone lysine methylation modifiers, namely ...
组蛋白 - 百度百科
组蛋白（histone）是真核生物体细胞染色质与原核细胞中的碱性蛋白质，和DNA共同组成核小体结构。 它们是染色质的主要蛋白质组分，作为DNA缠绕的线轴，并在基因调控中发挥作用，但是原核细胞组蛋白对基因调控的作用非常微弱。
Regulation of chromatin by histone modifications | Cell Research
2011年2月15日 · Histone modifications exert their effects via two main mechanisms. The first involves the modification(s) directly influencing the overall structure of chromatin, either over short or long...
Post‐translational modifications of histones: Mechanisms, …
2023年5月20日 · Histones are DNA‐binding basic proteins found in chromosomes. After the histone translation, its amino tail undergoes various modifications, such as methylation, acetylation, phosphorylation, ubiquitination, malonylation, propionylation, butyrylation, crotonylation, and lactylation, which together constitute the “histone code.”.
Histone - an overview | ScienceDirect Topics
Histone is a basic protein in eukaryotic cell chromatin and prokaryotic cell, which together with DNA constitute nucleosome structure (Eberharter and Becker 2002; Kouzarides 2007). Histone is composed of H1, H2A, H2B, H3 and H4 (Ramakrishnan 1997; Smith 1991).
Histone structure and nucleosome stability - PMC - National …
Histone modifications, structural changes & the molten globule state of the nucleosome core particle. Core histone tails can be reversibly modified by acetylation, methylation, ubiquitination and phosphorylation among others .
The secret life of histones | Science - AAAS
2020年7月3日 · Histone proteins are the ubiquitous organizers of all eukaryotic genomes (1). Two each of the histones H2A, H2B, H3, and H4 form a disk-shaped assembly around which 147 base pairs (bp) of DNA are tightly coiled. Hundreds of thousands of these connected nucleosomes wrap up further to form chromosomes.
- 某些结果已被删除