Endosomal PI(3)P regulation by the COMMD/CCDC22/CCDC93 (CCC ... - Nature
2019年9月19日 — CCC complex depletion leads to elevated PI (3)P levels, enhanced recruitment and activation of WASH (an actin nucleation promoting factor), excess endosomal F-actin and trapping of internalized...
Phosphatidylinositol-3-phosphate mediates Arc capsid secretion ... - PNAS
PI3P mediates Arc capsid trafficking and secretion through the endosome–MVB pathway. Arc protein is targeted to the limiting membrane of the early endosome through its interaction with PI3P (green), mediated by PI3K activity, and sorted through the axis of the late endosome and MVB. Endosomal PI3P could facilitate Arc oligomerization.
Phosphorylation of conserved phosphoinositide binding pocket …
2018年3月8日 — The paradigm of the superfamily is sorting nexin 3 (SNX3), which localizes to early endosomes by recognizing phosphatidylinositol 3-phosphate (PI3P) to initiate retromer-mediated segregation of...
Phosphatidylinositol-3-phosphate regulates sorting and ... - Nature
2013年8月2日 — Endosomal traffic is largely controlled by phosphatidylinositol-3-phosphate, a phosphoinositide synthesized primarily by lipid kinase Vps34. Here we show that...
Phosphatidylinositol‐3‐phosphate in the regulation of autophagy ...
2016年12月14日 — Phosphatidylinositol-3-phosphate (PI3P) is a key player in membrane dynamics and trafficking regulation. Most PI3P is associated with endosomal membranes and with the autophagosome preassembly machinery, presumably at the endoplasmic reticulum.
PI3P signaling regulates receptor sorting but not transport in the ...
2003年9月15日 — While evidence is accumulating that phosphoinositide signaling plays a crucial role in growth factor and hormone receptor down-regulation, this signaling pathway has also been proposed to regulate endosomal membrane transport and multivesicular endosome biogenesis. Here, we have followed the fate of …
Phosphoinositides signaling modulates microglial actin remodeling …
2021年2月24日 — PI3P synthesize by Vsp34 kinase has a fundamental role in endosomal membrane trafficking. PI3P deficiency correlates with endosome enlargement, disruption in APP processing, Aβ accumulation and defective intracellular aggregates clearance in AD .
Phosphatidylinositol 3‐phosphates—at the interface between cell ...
PI (3)P is a defining and essential feature of early endosomes and is generated primarily by the class III PI 3K Vps34 complex II with a possible contribution of class II PI 3Ks (encircled by dashed line), either by direct PI (3)P synthesis or indirectly via PI (3,4)P 2 hydrolysis by the PI 4‐phosphatases INPP 4A/B.
A Golgi-derived vesicle potentiates PtdIns4P to PtdIns3P ... - Nature
2021年6月28日 — Localized to the ER-mediated endosome fission site, the phosphatidylinositol transfer protein SEC14L2 promotes phosphatidylinositol 4-phosphate (PtdIns4P) to phosphatidylinositol 3-phosphate...
Phosphoinositides: Functions in autophagy-related stress …
2021年6月1日 — Autophagy initiation is believed to take place at endoplasmic reticulum (ER) subdomains enriched in PI3P (yellow hexagon), called omegasomes (in light blue). PI3P recruits PI3P-binding proteins such as DFCP1, WIPI2 and ATG16L1, thus …