The TP53 Gene and Its Role in Cancer - Verywell Health
2023年10月25日 — What is TP53 and what role does it play in cancer? The TP53 gene is a gene that is mutated in many cancers. It is the most common gene mutation found in cancer cells. A tumor-suppressor gene, TP53 codes for a protein that inhibits the development and growth of …
TP53 gene - MedlinePlus
The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). This protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells from growing and dividing (proliferating) too fast or in an uncontrolled way.
TP53 mutations in cancer: Molecular features and therapeutic ...
Mutations in the TP53 gene or functional inactivation of the p53 protein play a crucial role in cell transformation and the development of cancers. Missense nucleotide changes in the TP53 gene are the most frequent mutations observed in human cancers, making mutant p53 a key target for cancer research and development of therapies.
Tumor Suppressor p53: Biology, Signaling Pathways, and …
TP53 is a gene that encodes for the p53 tumor suppressor protein, commonly referred to as the “Guardian of the Genome” [1]. Its main biological function appears to involve the protection of the DNA integrity of the cell. TP53 plays additional roles …
TP53 Gene - GeneCards | P53 Protein | P53 Antibody
2024年10月2日 — p53 (TP53) is a transcription factor whose protein levels and post-translational modification state alter in response to cellular stress (e.g. hypoxia, DNA and spindle damage). Activation of p53 occurs by several mechanisms including phosphorylation by …
The TP53 Database
The TP53 Database compiles various types of data and information from the literature and generalist databases on human TP53 gene variations related to cancer. The database is hosted by the National Cancer Institute (NCI) of the United States.
TP53 tumor protein p53 [Homo sapiens (human)] - Gene - NCBI
2024年11月18日 — Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms.
Targeting p53 pathways: mechanisms, structures and advances in …
2023年3月1日 — Here, we provide a systematic review of the diverse molecular mechanisms of the p53 signaling pathway and how TP53 mutations impact tumor progression. We also discuss key structural features of...
Mutant p53 in cancer: from molecular mechanism to therapeutic ...
2022年11月18日 — TP53, a crucial tumor suppressor gene, is the most commonly mutated gene in human cancers. Aside from losing its tumor suppressor function, mutant p53 (mutp53) often acquires inherent, novel...
Tumor suppressor p53: Biology, signaling pathways, and ... - PubMed
TP53 is the most commonly mutated gene in human cancer with over 100,000 literature citations in PubMed. This is a heavily studied pathway in cancer biology and oncology with a history that dates back to 1979 when p53 was discovered.
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