高三尖杉酯碱 - 百度百科
高三尖杉酯碱，是一种有机化合物，化学式为C29H39NO9，为从三尖科植物三尖杉或其同属植物中得到的生物碱，可用作抗肿瘤药。 对 3 H标记的门冬酰胺掺入蛋白质有抑制作用，对 3 H标 …
Omacetaxine mepesuccinate - Wikipedia
Omacetaxine mepesuccinate (INN; trade name Synribo; formerly named as homoharringtonine or HHT) is a pharmaceutical drug substance that is indicated for treatment of chronic myeloid …
Homoharringtonine (Omacetaxine mepesuccinate，高三尖杉酯 …
Homoharringtonine (HHT) 抑制细胞生长、细胞活力和集落形成，并通过线粒体途径诱导细胞凋亡。 研究了 Homoharringtonine 对人 NSCLC 细胞系的细胞毒性，A549 (野生型 EGFR) 和 NCI …
Homoharringtonine: updated insights into its efficacy in …
2024年5月4日 · HHT has emerged as a notable compound in the realm of cancer treatment, particularly for hematological malignancies. Its multifaceted pharmacological properties extend …
Homoharringtonine inhibits the NOTCH/MYC pathway and …
2024年9月19日 · We report on the antileukemic activity of homoharringtonine (HHT) in T-cell acute lymphoblastic leukemia (T-ALL). We showed that HHT inhibited the NOTCH/MYC …
Nat Commun丨四川大学肖智雄/易勇团队揭示肿瘤抵抗核糖体毒性 …
2023年11月7日 · 研究表明，核糖体抑制剂通过激活J NK 、p 38 等信号通路产生核糖体毒性应激损伤（Ribotoxic Stress），从而促进肿瘤细胞凋亡。高三尖杉酯碱（Homoharringtonine, …
Homoharringtonine exhibits potent anti-tumor effect and ... - PubMed
Homoharringtonine, a plant alkaloid, has been reported to suppress protein synthesis and has been approved by the US Food and Drug Administration for the treatment of chronic myeloid …
Homoharringtonine: an effective new natural product in cancer ...
Homoharringtonine (HHT) is a cytotoxic alkaloid isolated from the evergreen tree cephalotaxus harringtonia native to the southern provinces of China. The principal mechanism of action of …
Homoharringtonine/Omacetaxine Mepesuccinate: The Long and …
Homoharringtonine/omacetaxine is a unique agent with a long history of research development. It has been recently approved by the Food and Drug Administration for the treatment of chronic …
Homoharringtonine and omacetaxine for myeloid …
2014年1月3日 · Homoharringtonine (HHT), a plant alkaloid with antitumor properties originally identified nearly 40 years ago, has a unique mechanism of action by preventing the initial …