2020年1月24日 · Volatile anesthetics induce hyperactivity during induction while producing anesthesia at higher concentrations. They also bidirectionally modulate many neuronal functions. However, the neuronal mechanism is unclear.

2024年1月4日 · Here, we report that, during anesthesia, dynamic microglial processes interact with neurons and shield axosomatic inhibitory inputs to transiently promote neuronal hyperactivity during...

2024年4月4日 · In this review, I will discuss (1) interfaces of anesthesia and sleep-wake mechanisms that physiologically regulate the level of consciousness, i.e., the global state of arousal; (2) effects of anesthetics on primary sensory processing; (3) anesthesia and the thalamocortical and cortical networks that are thought to mediate the content of ...

Anesthetics produce changes in the patient's behavioral state by interacting with brain activity via at least two mechanisms: the dose-dependent global and regionally specific suppression of neuronal activity and the disruption of functional interactivity within distributed neural networks.

General anesthetics can affect various neural functions of the central nervous system and produce general anesthesia [5, 6]. Among the relevant functions of central nervous system, synaptic transmission is the main procedure for information transmission between neurons and/or other cells [7, 8].

Microglial ablation or loss of microglial β2-adrenergic receptors prevents post-anesthesia neuronal hyperactivity. Our study demonstrates a previously unappreciated function of microglial process dynamics, which enable microglia to transiently boost post-anesthesia neuronal activity by physically shielding inhibitory inputs.

2019年6月5日 · Jiang-Xie et al. identified a specific group of hypothalamic neurons (AANs) commonly activated by multiple classes of general anesthetics. Stimulation of AANs potentiates slow-wave sleep and general anesthesia (GA), whereas inhibition of AANs disrupts natural sleep and destabilizes GA.

Volatile anesthetics induce hyperactivity during induction while producing anesthesia at higher concentrations. They also bidirectionally modulate many neuronal functions. However, the neuronal mechanism is unclear.

17 小时之前 · Conclusion Distinguishing anesthesia from sleep with neural oscillations could lead to more personalized, safer, and more effective approaches to managing consciousness in medical settings, with ...

2023年9月11日 · Our study identified pyramidal neuron hyperactivity in the anterior cingulate cortex (ACC) as a significant contributor to anesthesia-induced remote memory impairment. This ACC hyperactivation arises from the disinhibition of local inhibitory circuits and increased excitatory inputs from the hippocampal CA1 region.