Antibody-mediated activation of the FGFR1/Klothoβ complex
2020年11月17日 · Here we show that the bispecific anti-FGFR1/KLB agonist antibody BFKB8488A induced marked weight loss in obese cynomolgus monkeys while elevating …
活细胞中 Klothobeta (KLB) 和成纤维细胞生长因子受体 1 (FGFR1)
We confirmed that fluorescent protein-tagged KLB translocates to the plasma membrane and is active when co-expressed with FGFR1c. FGF21-induced signaling was enhanced in cells …
The FGF21 Receptor Signaling Complex: Klothoβ, FGFR1c, and …
We subsequently focus specifically on FGF21 signaling through FGFR1c and KLB, describing what is known about each protein's structure and how this drives protein interaction and …
Molecular elements in FGF19 and FGF21 defining KLB/FGFR activity …
2018年7月1日 · As expected, FGF21 was active in KLB/FGFR1 co-expressing cells (Figure 4 A), while inducing minimal signaling at KLB complexed with FGFR4-1c chimeric receptor, an …
The therapeutic potential of FGF21 in metabolic diseases: from …
2020年8月6日 · The binding of FGF21 to the FGFR1–β-klotho complex triggers autophosphorylation of FGFR1 and activation of the downstream MAPK signalling cascade …
Antibody-mediated activation of the FGFR1/Klothoβ complex ... - PNAS
Here we show that the bispecific anti-FGFR1/KLB agonist antibody BFKB8488A induced marked weight loss in obese cynomolgus monkeys while elevating serum adiponectin and the adipose …
Hepatocyte-specific fibroblast growth factor 21 overexpression ...
2021年11月3日 · FGF21 signaling requires co-receptor β-klotho (KLB) co-acting with FGF receptors, which has pleiotropic metabolic effects, including induced hepatic fatty acid …
Dynamics and Distribution of Klothoβ (KLB) and ... - ScienceDirect
2012年6月8日 · We measured the dynamics and distribution of fluorescent protein-tagged KLB and FGFR1c in living cells using fluorescence recovery after photobleaching and number and …
FGF19, FGF21, and an FGFR1/β-Klotho-Activating Antibody Act on …
2017年11月7日 · The Klb Camk2a knockout studies demonstrate that bFKB1 acts on neurons to affect body weight and circulating glucose and insulin levels despite its high molecular weight. …
Antibody-mediated activation of the FGFR1/Klothoβ complex ... - PNAS
2020年11月2日 · Fibroblast growth factor 21 (FGF21) controls metabolic organ homeostasis and eating behavior via FGF receptor 1/Klothoβ (FGFR1/KLB) complexes. Here we show that a …