2021年7月21日 · Pemphigus vulgaris is a rare autoimmune disease that is characterised by painful blisters and erosions on the skin and mucous membranes, most commonly inside the mouth. It accounts for 70% of all pemphigus cases worldwide. Images below show …

Pemphigus erythematosus (or Senear-Usher syndrome) is a variant of pemphigus foliaceus which shares clinical, histopathological, and serological features with systemic lupus erythematosus (SLE); they rarely coexist. It accounts for 10% cases of all pemphigus disease.

Using Nikolsky’s original definition strictly, his eponymous sign is the physical splitting of the epidermis creating an erosion (partial loss of the epidermis) following the application of a shearing force to the surface of the skin seen in pemphigus foliaceus. However, with time the use of the sign has broadened to include other intraepidermal disorders including pemphigus vulgaris …

Pemphigus may occur days, weeks, or as long as 6 months after the drug has been commenced. Who gets drug-induced pemphigus? Over 200 cases of drug-induced pemphigus have been reported in the medical literature. The reports suggest that patients with drug-induced pemphigus may have similar characteristics to non-drug-induced pemphigus.

Paraneoplastic pemphigus (PNP) is a rare, autoimmune, mucocutaneous, blistering disease that is almost always associated with a confirmed or occult neoplasm. The cause of PNP is not completely understood.

Pemphigus vulgaris is a chronic vesiculobullous skin disorder characterised by autoantibodies against desmoglein 3, which is a component of the desmosome (an intracellular adhesion molecule). Disruption of keratinocyte adhesion leads to superficial blistering and erosion affecting the skin and/or mucous membranes. Histology of pemphigus vulgaris

In SPD-type IgA pemphigus, the autoantigen is described as desmocollin 1, one of the desmosomal cadherins, the glycoproteins that maintain the shape of a cell. In at least some cases of IEN-type IgA pemphigus, the autoantigens are desmoglein 1, desmoglein 3, and an unspecified transmembrane protein. What is the differential diagnosis for IgA ...

DermNet pages about pemphigus. Benign familial pemphigus Brazilian pemphigus foliaceus Drug-induced pemphigus Endemic pemphigus foliaceus Familial benign pemphigus pathology IgA pemphigus Paraneoplastic pemphigus Paraneoplastic pemphigus pathology Pemphigus foliaceus Pemphigus foliaceus pathology Pemphigus vulgaris Pemphigus vulgaris images

IgA pemphigus: Typically there is a more prominent subcorneal neutrophilic infiltrate forming pustules. When there is only minor vesicle formation the clue to this diagnosis is in the predominance of neutrophils. Immunofluorescence show intercellular IgA deposition. Differential diagnosis of pemphigus foliaceus

Pemphigus vulgaris is a rare autoimmune disease that is characterised by painful blisters and erosions on the skin and mucous membranes, most commonly inside the mouth. View pictures of pemphigus vulgaris in the gallery below.