Targeting the biology of aging with mTOR inhibitors - Nature
2023年5月4日 · Inhibition of the protein kinase mechanistic target of rapamycin (mTOR) with the Food and Drug Administration (FDA)-approved therapeutic rapamycin promotes health and longevity in diverse model...
Rapamycin: one drug, many effects - PMC - PubMed Central (PMC)
The mammalian target of rapamycin (mTOR) signaling pathway is a master regulator of cell growth and metabolism. Deregulation of the mTOR pathway has been implicated in a number of human diseases such as cancer, diabetes, obesity, neurological diseases and genetic disorders.
Multifaceted role of mTOR (mammalian target of rapamycin) …
2023年10月2日 · The mammalian target of rapamycin (mTOR) is a protein kinase that controls cellular metabolism, catabolism, immune responses, autophagy, survival, proliferation, and migration, to maintain ...
Inhibition of the Mechanistic Target of Rapamycin (mTOR)–Rapamycin …
In this article, we discuss the molecular biology of mTOR, research into the mechanism by which mTOR inhibition promotes life span, the side effects of rapamycin, and possible ways in which rapamycin or alternative strategies to inhibit mTOR signaling may enable us to extend human life span and health span.
mTOR Signaling in Growth, Metabolism, and Disease - PMC
Despite these insights, the full mechanism of action of rapamycin remained elusive until 1994 when biochemical studies identified the mechanistic (formerly “mammalian”) Target of Rapamycin (mTOR) as the direct target of the rapamycin-FKBP12 complex in mammals (Brown et. al. 1994; Sabatini et. al. 1994; Sabers et. al 1995), and revealed it ...
Targeting ageing with rapamycin and its derivatives in humans: a ...
This finding suggests that even though the pharmacokinetics of rapamycin are well known, pharmacodynamic studies that focus on target (ie, mTOR) engagement and the effects of rapamycin on ageing-related biomarkers are needed to …
mTOR Signaling in Growth, Metabolism, and Disease - Cell Press
The mechanistic target of rapamycin (mTOR) coordinates eukaryotic cell growth and metabolism with environmental inputs, including nutrients and growth factors.
mTOR as a central hub of nutrient signalling and cell growth
2019年1月2日 · Mechanistic target of rapamycin (mTOR) controls cell growth mainly by promoting anabolic processes, including protein, lipid and nucleotide synthesis, and by suppressing catabolic processes, such...
Rapamycin: One Drug, Many Effects - Cell Press
The mammalian target of rapamycin (mTOR) signaling pathway is a master regulator of cell growth and metabolism. Deregulation of the mTOR pathway has been implicated in a number of human diseases such as cancer, diabetes, obesity, neurological diseases, and genetic disorders.
mTOR as a central regulator of lifespan and aging - PMC
Rapamycin, a natural product isolated from Streptomyces hygroscopicus, was discovered on the island of Rapa Nui in 1972 4. It possesses anti-fungal, immunosuppressive, and anti-cancer proprieties, which are mediated by the inhibition of its target: mechanistic/mammalian target of rapamycin (mTOR) 5– 7.
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