How regulatory T cells work | Nature Reviews Immunology
Regulatory T (T Reg) cells are essential for maintaining peripheral tolerance, preventing autoimmune diseases and limiting chronic inflammatory diseases. However, they also limit beneficial...
The regulation and differentiation of regulatory T cells and their ...
2024年2月19日 · The discovery of FOXP3+ regulatory T (Treg) cells as a distinct cell lineage with a central role in regulating immune responses provided a deeper understanding of self-tolerance.
Regulatory T cells: Purpose, Function & Development - Cleveland Clinic
2022年7月13日 · Regulatory T cells, also called Tregs, are white blood cells that regulate your immune system response. Tregs control how your immune system reacts to unwelcome substances from outside and inside your body.
How do Regulatory T Cells Work? - PMC - PubMed Central (PMC)
CD4+ T cells are commonly divided into regulatory T (Treg) cells and conventional T helper (Th) cells. Th cells control adaptive immunity against pathogens and cancer by activating other effector immune cells.
Regulatory T Cells: Mechanisms of Differentiation and Function
Regulatory T (Treg) cell–mediated suppression serves as a vital mechanism of negative regulation of immune-mediated inflammation and features prominently in autoimmune and autoinflammatory disorders, allergy, acute and chronic infections, cancer, and …
Principles of regulatory T cell function: Immunity - Cell Press
2023年2月14日 · Treg cells are an immunosuppressive lymphocyte subset essential for preventing autoimmunity. Dikiy and Rudensky review the mechanisms by which Treg cells prevent autoimmunity, mitigate inflammation, and support tissue function.
The development and function of regulatory T cells - PMC
Regulatory T cells (Tregs) are a critical subset of T cells that mediate peripheral tolerance. There are two types of Tregs: natural Tregs, which develop in the thymus, and induced Tregs, which are derived from naive CD4 + T cells in the periphery. Tregs utilize a variety of mechanisms to suppress the immune response.
Treg cell-based therapies: challenges and perspectives - Nature
2019年12月6日 · Cellular therapies using regulatory T (Treg) cells are currently undergoing clinical trials for the treatment of autoimmune diseases, transplant rejection and graft-versus-host disease.
Systems immunology of regulatory T cells: can one circuit explain …
2023年9月8日 · Regulatory T (Treg) cells play vital roles in immune homeostasis and response, including discrimination between self- and non-self-antigens, containment of immunopathology, and inflammation resolution. These diverse functions are orchestrated by cellular circuits involving Tregs and other cell types across space and time.
Regulatory T Cells (Tregs) | British Society for Immunology
As the name suggests regulatory T cells (also called Tregs) are T cells which have a role in regulating or suppressing other cells in the immune system. Tregs control the immune response to self and foreign particles (antigens) and help prevent autoimmune disease. Tregs produced by a normal thymus are termed ‘natural’.
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