In chemistry, hydroxylation refers to the installation of a hydroxyl group (−OH) into an organic compound. Hydroxylations generate alcohols and phenols, which are very common functional groups. Hydroxylation confers some degree of water-solubility. Hydroxylation of a hydrocarbon is an oxidation, thus a step in degradation.

羟基化 （hydroxylation）又称 羟化，是向 有机化合物 分子（底物）引入 羟基 （－OH）的过程；常指用羟基取代 碳 上的 氢 原子（－H）的反应。 产物是 醇 、 酚 等。 生化中，催化羟化反应的 酶 称为 羟化酶。

Protein hydroxylation is a post-translational modification (PTM) crucial for the structural integrity and functional diversity of proteins in living organisms. This modification involves the enzymatic addition of hydroxyl (-OH) groups to specific amino acids within a protein.

The hydroxylation occurs at the γ-Carbon atom of Proline, forming hydroxyproline (Hyp), which is an essential component of collagen occurring at every 3rd residue in its amino acid sequence. In some instances, hydroxylation of Proline at its β-Carbon may also occur. Lysine may be hydroxylated on the δ-C atom, forming hydroxylysine.

2019年3月15日 · Hydroxylation is an oxidation reaction in which carbon–hydrogen (C H) bond oxidizes into carbon–hydroxyl (C OH) bond. In organic chemistry, the hydroxylation reaction is mostly mediated by catalysts and heat. Most often the catalysts that mediates the hydroxylation reactions are metal ions.

2024年11月26日 · This review systematically summarizes the recent advances on the hydroxylation of NPs, such as amino acids, steroids, terpenoids, lipids, and phenylpropanoids, demonstrating the potential of synthetic biology strategies in constructing artificial biosynthetic pathways and producing hydroxylated natural product derivatives.

Hydroxylation is the process of introduction of a hydroxyl group (OH) via substitution of functional groups or hydrogen atoms and is usually catalyzed by either cytochrome P450-family enzymes (Staniek et al., 2013) or by 2-oxoglutarate-Fe (II)-ascorbate dependent dioxygenases (Forkmann and Heller, 1999).

Hydroxylation is the process of adding a hydroxyl group (-OH) to proteins, particularly collagen and elastin, to enhance tissue stability through protein cross-linking reactions. You might find these chapters and articles relevant to this topic. I. Lindberg, J.R. …

Hydroxylation is any chemical process that introduces one or more hydroxyl groups (-OH) into a compound (or radical) thereby oxidizing it. In biochemistry, hydroxylation reactions are often facilitated by enzymes called hydroxylases.

Using lysine derivatization with propionic anhydride to improve the analysis of tryptic peptides and nontryptic proteolysis, we report 150 sites of JMJD6-catalyzed lysine hydroxylation on 48 protein substrates, including 19 sites of hydroxylation on BRD4.