Identification of two new-type synthetic cannabinoids,
2012年4月11日 · In addition, five newly distributed cannabimimetic cannabinoids, AM-1248 (3), AM-1220 (4), AM-2233 (5), AM-1241 (6), and CB-13 (CRA-13, 7) were found in illegal products. The five compounds ( 3 – 7 ) have previously been shown to have binding affinity for cannabinoid CB 1 and/or CB 2 receptors and limited cannabimimetic effects, albeit only ...
Synthetic Cannabinoid Receptor Agonists - ScienceDirect
2013年1月1日 · However, a few compounds carrying polar groups like the 1-methylpiperidin-2-yl-methyl moiety (AM-1220, AM-2233, AM-1248) or the 2-morpholino-4-ylethyl moiety (WIN 48,098, JWH-200, WIN 55,212-2) have also appeared in ‘Spice’ products and show similar solubility in more polar solvents.
AM-1248 - Drugs-Forum
2013年10月4日 · AM-1248 is considered to be a research chemical, thus the long term and short term effects/side effects have yet to be formally established due to a lack of clinical trials. AM-1248 is a strong psychoactive substance, users whom have a known mental illness should avoid this compound as it may agitate the symptoms of such illness.
Abuse Potential of Synthetic Cannabinoids: AM-1248, CB-13, and …
2021年7月1日 · Europe PMC is an archive of life sciences journal literature.
groups (AM-1248 and CB-13) than that in the vehicle group, indicating their impulsive effects. In summary, these results demon- strated that SCBs have distinct pharmacological properties and abuse ...
Abuse Potential of Synthetic Cannabinoids: AM-1248, CB-13, and …
2021年5月3日 · The increase of active lever presses was particularly significant during the early IVSA sessions, indicating the reinforcement-enhancing effects of the SCBs (AM-1248 and CB-13). The number of inactive lever presses was significantly higher in the SCB groups (AM-1248 and CB-13) than that in the vehicle group, indicating their impulsive effects.
AM-1248 - Research chemicals exploring
Summary AM-1248 is a compound with disputed potency and selectivity, acting as a moderately potent agonist for both cannabinoid receptors CB1 and CB2. When the typical 3-(1-naphthyl) group found in many indole-derived cannabinoid ligands is replaced with an adamantyl group, it often imparts significant CB2 selectivity. However, by incorporating an N-methylpiperidin-2-ylmethyl substitution at ...
AM-1248 - National Center for Advancing Translational Sciences
AM-1248 5EX9HEF4HK Other Structure General Activity Names 5: Classification 1: Identifiers 5: Related Substances 1: AM-1248 5EX9HEF4HK Other Details Stereochemistry: RACEMIC Molecular Formula: C26H34N2O: Molecular Weight: 390.561: Optical Activity ( + / - ) ...
Abuse Potential of Synthetic Cannabinoids: AM-1248, CB-13, and …
Currently, the expanding recreational use of synthetic cannabinoids (SCBs) threatens public health. SCBs produce psychoactive effects similar to those of tetrahydrocannabinol, the main component of cannabis, and additionally induce unexpected pharmacological side effects. SCBs are falsely advertised as legal and safe, but in reality, SCB abuse has been reported to cause acute intoxication and ...
The major peak at retention time 24.019 minutes is AM1248; while the shoulder at retention time 24.114 minutes is a suspected synthesis byproduct consisting of an azepane isomer. (Citation: “Identification. of the cannabimimetic AM-1220 and its azepane isomer (N-methylazepan-3yl)-3-(1-naphthoyl)indole in a research chemical and several herbal ...
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