AMPK activation by prolonged stimulation with interleukin-1β ...
Stimulation with IL-1β for 24 h significantly increased AMP-activated protein kinase (AMPK) phosphorylation and GLUT4 protein expression. Small interfering RNA (siRNA) targeting …
AMPK activation attenuates inflammatory pain through inhibiting …
2019年2月12日 · Our study provides new information that AMPK activation produces the analgesic effect by inhibiting NF-κB activation and reducing the expression of IL-1β in …
Mechanistically, reduced choline up-take altered mitochondrial lipid profile, attenuated mitochondrial ATP synthesis, and activated the en-ergy sensor AMP-activated protein kinase …
AMPK activation attenuates inflammatory pain through inhibiting …
2019年2月12日 · Our study provides new information that AMPK activation produces the analgesic effect by inhibiting NF-κB activation and reducing the expression of IL-1β in …
JNK activation is essential for activation of MEK/ERK signaling in IL …
2017年1月5日 · IL-1β, a cytokine involved in the inflammatory response, induces prostaglandin E 2 synthesis via cyclooxygenase-2 (COX-2) expression in proinflammatory states 6, 10, 11, 12. …
Activation of AMP-activated protein kinase rapidly suppresses …
2017年1月15日 · Furthermore, we demonstrate that AMPK-mediated suppression of IL-1β-stimulated pro-inflammatory signalling in adipocytes is associated with reduced …
AMPK signaling in diabetes mellitus, insulin resistance and diabetic ...
2022年2月1日 · The activation of AMPK signaling enhances PGC-1α expression, resulting in CPT-1B overexpression and preventing lipid dysfunction. This axis not only reduces oxidative …
Choline uptake and metabolism modulate macrophage IL-1β and IL …
Mechanistically, reduced choline uptake altered mitochondrial lipid profile, attenuated mitochondrial ATP synthesis and activated the energy sensor AMP-activated protein kinase …
Choline Uptake and Metabolism Modulate Macrophage IL-1β and IL …
2019年6月4日 · Mechanistically, reduced choline uptake altered mitochondrial lipid profile, attenuated mitochondrial ATP synthesis, and activated the energy sensor AMP-activated …
Metformin attenuates hypothalamic inflammation via downregulation …
2021年11月8日 · Here, we demonstrate that microglial necroptosis plays a pivotal role in obesity-related hypothalamic inflammation, facilitating proinflammatory cytokine production, such as …