Microglia in neuropathic pain: cellular and molecular ... - Nature
2018年2月8日 · It is also becoming clear that microglia have active roles in brain regions important for the emotional and memory-related aspects of chronic pain. Recent advances in the development of new...
Review Microglia in Pain: Detrimental and Protective Roles in ...
2018年12月19日 · Numerous signaling molecules are altered in microglia and contribute to the pathogenesis of pain. Here, we discuss how microglial signaling regulates spinal cord synaptic plasticity in acute and chronic pain conditions with different degrees and variations of microgliosis.
Neuropeptides and Microglial Activation in Inflammation, Pain, …
In experimental models of pain, certain neuropeptides such as SP, CGRP, and AM have been suggested to increase pain hypersensitivity partly by promoting proinflammatory activation of spinal cord microglia.
Neuroplasticity related to chronic pain and its modulation by microglia
2022年5月3日 · Recent studies have shown that neuroplasticity is linked to causing neuropathic pain in response to nerve damage, which may occur adjacent to or remotely from the site of injury. Furthermore, studies have revealed that neuroplasticity relevant to chronic pain is modulated by microglia, resident immune cells of the central nervous system (CNS).
Microglia in Pain: Detrimental and Protective Roles in …
Numerous signaling molecules are altered in microglia and contribute to the pathogenesis of pain. Here, we discuss how microglial signaling regulates spinal cord synaptic plasticity in acute and chronic pain conditions with different degrees and variations of microgliosis.
Microglia in Pain: Detrimental and protective roles in …
Numerous signaling molecules are altered in microglia and contribute to the pathogenesis of pain. Here we discuss how microglial signaling regulates spinal cord synaptic plasticity in acute and chronic pain conditions with different degrees and variations of microgliosis.
Microglia in neuropathic pain: cellular and molecular ... - PubMed
It is also becoming clear that microglia have active roles in brain regions important for the emotional and memory-related aspects of chronic pain. Recent advances in the development of new drugs targeting microglia and the establishment of new sources of human microglia-like cells may facilitate translation of these findings from bench to bedside.
Microglia in neurodegenerative diseases: mechanism and …
2023年9月22日 · Microglia activation is observed in various neurodegenerative diseases. Recent advances in single-cell technologies have revealed that these reactive microglia were with high spatial and...
Role of macrophages and activated microglia in neuropathic pain ...
2019年10月30日 · Our results suggested that chronic neuropathic pain in long-term spinal cord compression correlates with infiltrating macrophages, activated microglial cells and the associated damage of BSCB,...
Central Nervous System Targets: Glial Cell Mechanisms in Chronic Pain …
2020年8月20日 · In this review, we highlight the changes that reactive microglia and astrocytes undergo following painful injuries and insults and discuss the critical and interactive role these two cell types play in the initiation and maintenance of chronic pain.
- 某些结果已被删除