Akt/PKB regulates actin organization and cell motility via
Here, we identify an Akt substrate, designated Girdin/APE (Akt-phosphorylation enhancer), which is an actin binding protein. Girdin expresses ubiquitously and plays a crucial role in the formation of stress fibers and lamellipodia.
Akt/PKB Regulates Actin Organization and Cell Motility via …
2005年9月1日 · Here, we identify an Akt substrate, designated Girdin/APE (Akt-phosphorylation enhancer), which is an actin binding protein. Girdin expresses ubiquitously and plays a crucial role in the formation of stress fibers and lamellipodia.
AKT kinases as therapeutic targets | Journal of Experimental
2024年11月29日 · AKT, or protein kinase B, is a central node of the PI3K signaling pathway that is pivotal for a range of normal cellular physiologies that also underlie several pathological conditions, including inflammatory and autoimmune diseases, overgrowth syndromes, and neoplastic transformation.
STING couples with PI3K to regulate actin reorganization ... - Science
2020年4月22日 · We found that STING negatively regulates BCR signaling by suppressing the CD19-PI3K-Btk proximal axis and the Akt-mTORC1 distal axis, and by enhancing the activation of SHIP, which also negatively regulates the actin reorganization.
Biochemical and mechanical regulation of actin dynamics
2022年8月2日 · By using an updated view of actin dynamics as a framework, we discuss how the mechanics and geometry of actin networks control actin-binding proteins, and how this translates into force...
Defining the Akt1 interactome and its role in regulating the
2018年1月22日 · Beta-actin (ACTB) is a non-muscle cytoskeletal actin involved in cell motility, structure and integrity.
Retraction: Pemetrexed Induces S-Phase Arrest and Apoptosis via …
2 天之前 · The following concerns were identified with the Akt and β-actin panels in Figure 1A: The full panels appear similar to each other. Lanes 1–4 appear similar to the Akt panel in Figure 1B. Lanes 3–5 appear similar to the β-actin panel in Figure 6C. The β-actin panel in Figure 1B appears similar to the β-actin panel in Figure 5B.
Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis
Akt is a critical protein kinase that drives cancer proliferation, modulates metabolism, and is activated by C-terminal phosphorylation. The current structural model for Akt activation by C-terminal phosphorylation has centered on intramolecular interactions between the C-terminal tail and the N lobe of the kinase domain.
Spatial Coordination of Actin Polymerization and ILK–Akt2 …
2009年5月19日 · Eukaryotic cell migration proceeds by cycles of protrusion, adhesion, and contraction, regulated by actin polymerization, focal adhesion assembly, and matrix degradation. However, mechanisms coordinating these processes remain largely unknown.
Proteomics Exploration Reveals That Actin Is a Signaling Target …
The results show that actin was recognized by PAS antibody under cell stimulation by FGF-2 and that actin phosphorylation was inhibited by wortmannin, thereby indicating that actin is a phosphorylation target of Akt signaling.
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