Organolithium reagent - Wikipedia
In organometallic chemistry, organolithium reagents are chemical compounds that contain carbon – lithium (C–Li) bonds. These reagents are important in organic synthesis, and are frequently used to transfer the organic group or the lithium atom to the substrates in synthetic steps, through nucleophilic addition or simple deprotonation. [1]
Grignard and Organolithium Reagents - Chemistry LibreTexts
2023年1月23日 · The following equations illustrate these reactions for the commonly used metals lithium and magnesium (R may be hydrogen or alkyl groups in any combination). An Alkyl Lithium Reagent \[ \ce{R3C-X} + \ce{2Li} \rightarrow \ce{R3C-Li} + \ce{LiX}\]
3.4: Organolithium Compounds - Chemistry LibreTexts
Alkyl lithium compounds are either low melting solids or liquids, and often with high volatility (depending on the substituent) due to the covalent nature of the bonding. They are soluble in aliphatics, aromatics, and ethers.
Formation of Grignard and Organolithium Reagents From Alkyl ...
2015年11月9日 · To make organolithium reagents, we start with alkyl halides, and add powdered lithium metal (Li or sometimes written as Li 0 to distinguish it from the ion Li(+) ). Occasionally the solvent for this reaction is written below the arrow.
Alkyllithium Compound - an overview | ScienceDirect Topics
Alkyllithium compounds interact with organometallic compounds of different metals (MtR′n), most notably those of Groups I, II, and III, which behave like Lewis acids, to form mixed organometallic compounds, referred to as ‘ate’ complexes, 61 schematically represented in the following equation: 61. [5]
Lithium diisopropylamide and related bases have made routinely available solutions of regioisomerically pure lithium enolates derived from ketones, some aldehydes, carboxylic acids, esters, lactones, amides and lactams. Many di- and tri-anions have also been prepared.[4] Hence many alkylations, acylations and other reactions of enolates
200 Years of Lithium and 100 Years of Organolithium Chemistry
2018年3月1日 · Many lithium salts are important ingredients especially for eutectic mixtures with other metal salts. Amongst all alkali metals, lithium has the highest electronegativity and heat capacity. Lithium's standard electrode potential is –3.045 V, which is the lowest of all elements.