Calcium Channel Blocker–Induced Lower-Extremity Edema and …
2019年12月27日 · Moreover, we identified a higher aSR among men, patients initially prescribed amlodipine, patients initially prescribed a high-dose DH CCB, and patients receiving 1 or fewer other antihypertensive classes, suggesting a higher likelihood of inappropriately prescribed loop diuretics for edema within these subpopulations.
Why Amlodipine Causes Ankle Swelling and How to Reduce It
2024年10月24日 · Amlodipine, sold as a generic drug or as the Katerzia and Norvasc brands, often causes ankle edema. This is an abnormal swelling of tissues due to fluid buildup. Swollen feet are a common side effect experienced by about 16% …
Leg edema with (S)-amlodipine vs conventional amlodipine …
Leg edema is a common adverse effect of dihydropyridine Calcium Channel Blockers (CCB) that may need dose reduction or drug withdrawal, adversely affecting the antihypertensive efficacy. Leg edema is reported to occur less often with (S)-amlodipine compared to …
Pedal edema—not all dihydropyridine calcium antagonists are …
2002年11月1日 · In this multicenter, double blind, parallel group study of more than 800 elderly patients, amlodipine had a significantly (P < .001) higher rate of pedal edema (19%) compared with lercanidipine (9%) and lacidipine (4%).
Amlodipine - StatPearls - NCBI Bookshelf
2024年4月21日 · Amlodipine is an oral dihydropyridine calcium channel blocker. The United States Food and Drug Administration (FDA) initially approved amlodipine besylate in 1987. FDA-Approved Indications. Hypertension: Amlodipine is an excellent first-line choice among the multiple options of antihypertensive agents.
CCBs are used as antihypertensive drugs, Common ADR of them is Peripheral edema (Up to 10.8%), with amlodipine Incidence is Up to 10.8% [7] and with nifedipine Incidence is 7% to 29%. A Prospective and retrospective pilot study was conducted in tertiary care centers.
Amlodipine-Induced Pedal Edema and Its Relation to Other …
When used as monotherapy, calcium channel blockers (CCBs) are associated with a substantial risk of peripheral edema, including pedal edema, which is the most common reason for its discontinuation. 1 This is a dose-dependent adverse effect, so low-dose combination therapy is a preferred choice over high-dose monotherapy.
Management of amlodipine-induced ankle oedema - PubMed
2023年4月17日 · Pedal oedema is a well-known adverse effect of amlodipine, but significantly less frequent if only half of the maximum recommended dosage is used. Diuretics are ineffective. To cause as few side effects as possible, options for managing are prioritised in this review: Reduce dosage, switch to lercan …
Managing Calcium Channel Blocker-Related Peripheral Edema
2007年5月25日 · Peripheral edema is more likely to occur with dihydropyridine CCBs. One study noted 272/2000 (13.6%) patients reporting edema with CCB monotherapy, slightly but not significantly more common in women than men (15.6% vs. 11.8%), 1 with the varying prevalence according to the specific agent (Table).
Managing Calcium Channel Blocker‐Related Peripheral Edema
Two major hypertension trials involving CCBs have reported edema rates: the second Swedish Trial in Old Patients with Hypertension (STOP‐2) noted that 25.5% of patients treated with either felodipine or isradipine had edema; 5 and Intervention as a Goal in Hypertension Treatment (INSIGHT) study patients reported a 28% incidence of edema while ta...
跳至内容