Autophagy - Wikipedia
Autophagy (or autophagocytosis; from the Greek αὐτόφαγος, autóphagos, meaning "self-devouring" [ 1 ] and κύτος, kýtos, meaning "hollow") [ 2 ] is the natural, conserved degradation of the cell that removes unnecessary or dysfunctional components through a lysosome-dependent regulated mechanism. [ 3 ]
Autophagy pathway: Cellular and molecular mechanisms - PMC
2017年12月31日 · The autophagy pathway starts at the birth of the phagophore and ends at death of the autophagosome. The cellular and molecular lifecycle of this pathway has occupied cell biologists since the late 1950s.
Autophagy: Regulator of cell death | Cell Death & Disease - Nature
2023年10月4日 · Autophagy is the process by which cells degrade and recycle proteins and organelles to maintain intracellular homeostasis. Generally, autophagy plays a protective role in cells, but disruption...
Autophagy pathway: Cellular and molecular mechanisms
This review will define this process and the cellular pathways required, from the formation of the double membrane to the fusion with lysosomes in molecular terms, and in particular highlight the recent progress in our understanding of this complex process.
An Overview of Autophagy: Morphology, Mechanism, and Regulation
2014年1月1日 · Introduction. A utophagy is a cellular degradation and recycling process that is highly conserved in all eukaryotes. In mammalian cells, there are three primary types of autophagy: microautophagy, macroautophagy, and chaperone-mediated autophagy (CMA).
Autophagy: cellular and molecular mechanisms - PMC
Autophagy is a complex self-degradative process that involves the following key steps: (a) control of phagophore formation by Beclin-1/VPS34 at the ER and other membranes in response to stress signalling pathways; (b) Atg5–Atg12 conjugation, interaction with Atg16L and multimerization at the phagophore; (c) LC3 processing and insertion into ...
The autophagy-lysosomal pathway - Neurology
2015年7月22日 · Autophagy (derived from the Greek words for self and eating) includes 3 major types: microautophagy, chaperone-mediated autophagy (CMA), and macroautophagy; all these pathways eventually lead to cargo degradation by the lysosome.
Autophagy genes in biology and disease - Nature
2023年1月12日 · Autophagy (‘self-eating’) is a collection of processes by which cellular components such as proteins and organelles are delivered to the lysosome or vacuole for degradation. Two autophagy...
The mechanisms and roles of selective autophagy in mammals
2022年10月27日 · Autophagy is a mechanism conserved in eukaryotes, from yeast to humans, and is involved in maintaining cellular homeostasis by degrading organelles, proteins, lipids, and nucleic acids and...
Autophagy: Renovation of Cells and Tissues - Cell Press
Autophagy is a generic term for all pathways by which cytoplasmic materials are delivered to the lysosome in animal cells or the vacuole in plant and yeast cells. There are roughly three classes of autophagy (Figure 1): macroautophagy, microautophagy, and chaperone-mediated autophagy.
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