MHC分子、APC细胞及T细胞之间的关联及详解 - 知乎
2023年5月12日 · t细胞是一种免疫细胞，主要分为两大类：cd4+和cd8+ t细胞。 它们通过识别和结合APC细胞上的MHC-抗原复合物来激活免疫反应。 具体而言，CD4+ T细胞可以与MHC-II分子上的抗原结合，从而激活B细胞、巨噬细胞和其它T细胞等；而CD8+ T细胞则可以与MHC-I分子上的 …
一文读懂MHC多肽复合体：免疫系统调控的关键角色 - 知乎
2023年12月8日 · CD4分子负责辅助性T细胞识别MHC II类分子，而CD8分子则用于细胞毒性T细胞识别MHC I类分子。 相反，表达γδ型T细胞受体的T细胞既不表达CD4也不表达CD8。 在胸腺中，αβT细胞经历“培训”以确保其不对自身肽段产生反应。 然而，对于γδT细胞受体，其“培训”机制仍存有许多未解之谜。 例如，我们尚不清楚这些细胞是如何被“培训”的。 尽管γδT细胞存在于胸腺中，但缺乏功能性胸腺的裸鼠仍能产生γδT细胞。 在大多数情况下，我们并不清楚γδT细胞能识 …
T Cells and MHC Proteins - Molecular Biology of the Cell - NCBI …
CD4 is expressed on helper T cells and binds to class II MHC proteins, whereas CD8 is expressed on cytotoxic T cells and binds to class I MHC proteins (Figure 24-55). Thus, CD4 and CD8 contribute to T cell recognition by helping to focus the cell on particular MHC proteins, and thus on particular types of cells—helper T cells on dendritic ...
The order and logic of CD4 versus CD8 lineage choice and
2021年1月4日 · Our data show that selection intermediates discriminate MHC class prior to the loss of coreceptor expression and suggest a model where signal strength informs the timing of coreceptor gene...
免疫系统的细胞成分 - 免疫系统的细胞成分 - MSD诊疗手册专业版
T细胞受体（TCR）上的alpha和beta肽链与抗原呈递细胞（APC）上的由主要组织相容性复合物（MHC）递呈的抗原结合，同时CD4或CD8与结合MHC分子。 T细胞的两种活化（第一信号）都依赖CD3链的辅助。
CD4 and CD8 binding to MHC molecules primarily acts to …
2010年9月9日 · We developed a model of TCR and coreceptor binding and activation and find that these results can be explained by relatively small differences in the MHC binding properties of CD4 and CD8 that furthermore suggest that the role of the coreceptor in the targeted delivery of Lck to the relevant TCR-CD3 complex is their most important function.
Conversion of effector CD4+ T cells to a CD8+ MHC II ... - Nature
2020年2月17日 · We define a novel CD4 − CD8αβ + MHC II-recognizing population generated by lineage conversion from effector CD4 + T cells. CD4 − CD8αβ + effector T cells downregulated the expression of T...
Single-cell multiomic analysis of thymocyte development ... - Nature
2023年8月14日 · Recognition of self-peptide major histocompatibility complex (MHC) class I or II by the T cell antigen receptor (TCR) determines the CD8 + or CD4 + T cell lineage choice, respectively, but...
CD4-CD8 differentiation in the thymus: connecting circuits and …
CD4 T cells are MHC-II restricted and pre-programmed for helper functions, whereas CD8 T cells are MHC I-restricted and pre-programmed for cytotoxic functions. CD4 and CD8 subsets constitute the bulk of αβ T cells and are the main component of T-mediated immune responses.
Conversion of effector CD4+ T cells to a CD8+ MHC II …
We define a novel CD4-CD8αβ + MHC II-recognizing population generated by lineage conversion from effector CD4 + T cells. CD4 - CD8αβ + effector T cells downregulated the expression of T helper cell-associated costimulatory molecules and increased the expression of cytotoxic T lymphocyte-associated cytotoxic molecules.
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