CD4 + T cells in cancer - Nature
2023年3月9日 · Recent progress highlights the importance of CD4 + T cells, corresponding to the long-known fact that CD4 + T cells are central players and coordinators of innate and antigen-specific...
Regulation and impact of tumor-specific CD4+ T cells in cancer …
2024年3月19日 · CD4+ T cells are crucial for enhancing the functions of antigen-presenting cells, increasing CD8+ T cell effector differentiation, driving B cell activation and antibody affinity maturation, and temporally sustaining immune efficacy during cancer progression.
Revisiting the role of CD4+ T cells in cancer …
2020年5月27日 · CD4 + T cells primarily mediate anti-tumour immunity by providing help for CD8 + CTL and antibody responses, as well as via secretion of effector cytokines such as interferon-γ (IFNγ) and...
Differentiation fate of a stem-like CD4 T cell controls immunity to cancer
2024年10月23日 · Primarily residing in tumour-draining lymph nodes (TDLNs), these tumour-specific CD4 T cells are restricted by T regulatory (T reg) cells to a stem-like fate that predominantly generated...
CD8 + T cells in the cancer-immunity cycle - Cell Press
CD8+ T cells are “end effectors” of cancer immunity. Wherry, Kaech, and colleagues review the current understanding of CD8+ T cell differentiation and function in cancer, discussing recent advances within a four-signal framework that incorporates T cell metabolism and the impact of the tumor microenvironment.
Immune cell triads reprogram exhausted CD8+ T cells for effective tumor …
2024年7月8日 · MHC class I and class II antigens expressed by the same tumor cell force the formation of triads between antigen-specific CD4 + and CD8 + T cells and APCs, reprogramming exhausted CD8 + T cells to exert increased effector functions.
CD4 and CD8 T lymphocyte interplay in controlling tumor growth
In this review, we give an overview of T lymphocyte-driven control of tumor growth and discuss the involved tumor-suppressive mechanisms of the immune system, such as senescence surveillance, cancer immunosurveillance, and cancer immunoediting with respect to recent clinical developments of immunotherapies.
Tumor-specific cytolytic CD4 T cells mediate immunity against
Here, by mining single-cell RNA-seq datasets, we identified CD4 T cell clusters displaying cytotoxic phenotypes in different human cancers, resembling CD8 T cell profiles. Using the peptide-MHCII-multimer technology, we confirmed ex vivo the presence of …
CD3+CD4-CD8- (Double-Negative) T Cells in Inflammation, …
2022年2月10日 · CD3 + CD4 - CD8 - double-negative (DN) T cells, although constituting a rare subset of peripheral T cells, are gaining interest for their roles in inflammation, immune disease and cancer. Herein, we comprehensively review the origin, distribution and functions of this unique T cell subgroup.
Single-cell transcriptomics identifies multiple pathways underlying ...
Transgenic coexpression of a class I–restricted tumor antigen–specific T cell receptor (TCR) and CD8αβ (TCR8) redirects antigen specificity of CD4 + T cells.
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