Similarities and differences in CD4+ and CD8+ effector and …
2003年9月1日 · Recent evidence indicates that both cell-intrinsic and cell-extrinsic factors regulate memory T cell differentiation. This review compares and contrasts how naive CD4 + and CD8 + T cells make...
Structural and Biophysical Insights into the Role of CD4 and CD8 …
Here we review structural and biophysical studies of CD4 and CD8 interactions with MHC molecules and TCR–pMHC complexes. Crystal structures have been determined of CD8αα and CD8αβ in complex with MHC class I, of CD4 bound to MHC class II, and of a complete TCR–pMHC–CD4 ternary complex.
The order and logic of CD4 versus CD8 lineage choice and
2021年1月4日 · CD4 helper T cells and CD8 cytotoxic T cells are the two principal T cell lineages in the mammalian immune system. Although distinct in phenotype and function, CD4 and CD8 T cells arise in...
Structure, function, and immunomodulation of the CD8 co-receptor
2024年8月25日 · We outline the unique structure and function of different CD8 domains (ectodomain, hinge, transmembrane, cytoplasmic tail) in the context of the distinct properties of CD8αα homodimers and CD8αβ heterodimers. We discuss CD8 features commonly used to construct chimeric antigen receptors for immunotherapy.
CD4-CD8 differentiation in the thymus: connecting circuits and …
CD4 T cells are MHC-II restricted and pre-programmed for helper functions, whereas CD8 T cells are MHC I-restricted and pre-programmed for cytotoxic functions. CD4 and CD8 subsets constitute the bulk of αβ T cells and are the main component of T-mediated immune responses.
Lineage fate and intense debate: myths, models and mechanisms of CD4 …
Classical models of CD4/CD8-lineage choice share the perspective that lineage choice occurs in thymocytes that express both Cd4 and Cd8 at the mRNA level (that is, transcriptionally...
Molecular Biology and Function of CD4 and CD8 - ScienceDirect
1989年1月1日 · The correlation between CD4 and CD8 expression and the class of MHC protein recognized led to the hypothesis that CD4 and CD8 might be receptors for nonpolymorphic (or relatively nonpolymorphic) regions on class I and class I1 MHC proteins, respectively (Krensky et al., 1982a; Meuer et al., 1982a.b; Ball and Stastny, 1982; Spits et al., 1982 ...
Development of the CD4 and CD8 lineage of T cells: instruction versus …
T cells bearing the alpha beta T cell receptor (TCR) can be divided into CD4+8- and CD4-8+ subsets which develop in the thymus from CD4+8+ precursors. The commitment to the CD4 and CD8 lineage depends on the binding of the alpha beta TCR to thymic major histocompatibility complex (MHC) coded class II and class I molecules, respectively.
A structural view of CD4 and CD8 - PubMed
CD4 and CD8 are cell-surface glycoproteins that participate in molecular complexes involved in both T cell development and antigen recognition by T cells. CD4 and CD8 interact with nonpolymorphic regions of class II and class I major histocompatibility complex (MHC) molecules, respectively, and thes …
Crystal structures of extracellular regions of CD4 and CD8 have been determined and have provided a basis for understanding and probing CD4 and CD8 function. The structures of CD4 and CD8 are reviewed here, along with the implications of these structures for CD4 and CD8 function.-Leahy, D. J. A structural view of CD4 and CD8. FASEBJ. 9, 17-25 ...