T cell-mediated cytotoxicity - Immunobiology - NCBI Bookshelf
Armed effector cytotoxic CD8 T cells are essential in host defense against pathogens that live in the cytosol, the commonest of which are viruses. These cytotoxic T cells can kill any cell harboring such pathogens by recognizing foreign peptides that are transported to the cell surface bound to MHC class I molecules.
Cytotoxic CD8 + T cells in cancer and cancer immunotherapy
2020年9月15日 · Cytotoxic T cells expressing cell-surface CD8 are the most powerful effectors in the anticancer immune response and form the backbone of current successful cancer immunotherapies.
CD8 + T cells maintain killing of MHC-I-negative tumor cells …
2023年8月3日 · Here, we characterize an MHC-I- and antigen-independent CD8 + T cell mechanism for tumor cell
Cytotoxic T cells are able to efficiently eliminate cancer cells by ...
2021年9月1日 · Nature Communications - Cytotoxic CD8+ T lymphocytes (CTL) often fail to kill tumour cells in one-to-one interactions. Here the authors show that these sublethal interactions from multiple CTL...
Mechanisms and Dynamics of T Cell-Mediated Cytotoxicity In Vivo
2017年6月1日 · In principle, factors such as a very low CD8 T cell precursor frequency, inefficient CTL entry into the infected or tumor tissue, or immune evasion in the target cell might constitute bottlenecks in the CTL response that can completely abrogate killing.
Following antigen-receptor-mediated activation, CD8 T cells start to proliferate and differentiate into effector cells named CTLs. These effector cells are able to kill and eradicate infected or malignant cells and can help to provide protection against infections or cancer.
Mechanisms and Dynamics of T Cell-Mediated Cytotoxicity
2017年5月9日 · In principle, factors such as a very low CD8 T cell precursor frequency, inefficient CTL entry into the infected or tumor tissue, or immune evasion in the target cell might constitute bottlenecks in the CTL response that can completely abrogate killing.
Molecular mechanisms of CD8+ T cell trafficking and localization
To fully achieve this objective, naïve CD8 + T cells must be able to survey the entire body for the presence of foreign or “non-self” antigen that is delivered to draining lymph nodes following infection or tissue injury.
CD8 + T cells in the cancer-immunity cycle - Cell Press
CD8 + T cells are end effectors of cancer immunity. Most forms of effective cancer immunotherapy involve CD8 + T cell effector function. Here, we review the current understanding of T cell function in cancer, focusing on key CD8 + T cell subtypes and states.
CD8+ T Cell-Independent Immune-Mediated Mechanisms of Anti …
CD8 + T cell cytotoxic activity has long been proposed as the primary effector function necessary for tumor regression. However, there is increasing evidence that indicates that components of the immune system other than CD8 + T cells play important roles in tumor eradication and control.