CD8 T-cell subsets: heterogeneity, functions, and therapeutic …
2023年11月1日 · This review highlights recent advancements in our understanding of CD8 T-cell subsets and the contributions of these cells to various disease pathologies.
CD8 T-cell subsets: heterogeneity, functions, and therapeutic
2023年11月1日 · However, emerging evidence suggests distinct subsets of effector CD8 T cells that each exhibit unique effector functions and therapeutic potential. This review highlights …
The Roles of CD8 + T Cell Subsets in Antitumor Immunity - PubMed
These subsets, referred to as the Tc subsets, have also been detected in tumor microenvironments (TMEs), where they potentially influence the antitumor response and …
Conventional T cell populations consist of CD4 T cells and CD8 T cells that recognize cognate antigenic peptides presented by MHC class II and I molecules, respectively.
The Roles of CD8 + T Cell Subsets in Antitumor Immunity - Cell …
2020年7月2日 · Effector CD8+ T cells are typically thought to be a homogenous group of cytotoxic cells that produce interferon-(IFN) γ. However, recent findings have challenged this notion …
Overview of T Cell Subsets - Immunopaedia
Cytokines that Determine T-cell Subsets. Specific cytokines are involved in shaping the two subsets of the T-cell system: CD4+ Thelper (Th) and CD8+ Cytotoxic T Lymphocytes (CTL)
Subsets of exhausted CD8 + T cells differentially mediate ... - Nature
2019年2月18日 · To define the basis for T cell dysfunction in TILs, we compared single-cell expression profiles of exhausted CD8 + T cells during chronic viral infection with those of CD8 …
Defining Memory CD8 T Cell - Frontiers
2018年11月19日 · Heterogeneity within memory CD8 T cell subsets uncovered by recent subsetting strategies discussed in this review also highlights the limitations of ascribing …
Different Subsets of T Cells, Memory, Effector Functions, and CAR-T ...
2016年3月15日 · This review is focused on different subsets of T cells: CD4 and CD8, memory and effector functions, and their role in CAR-T therapy--a cellular adoptive immunotherapy …
Developmental Relationships of Four Exhausted CD8 + T Cell Subsets ...
2020年5月11日 · Beltra et al. define a hierarchical developmental pathway for CD8+ T cell exhaustion, revealing four stages and multistep transcriptional and epigenetic dynamics …