ENTPD1 - Wikipedia
Ectonucleoside triphosphate diphosphohydrolase-1 (gene: ENTPD1; protein: NTPDase1) also known as CD39 (Cluster of Differentiation 39), is a typical cell surface enzyme with a catalytic …
CD39 Regulation and Functions in T Cells - MDPI
2021年7月28日 · Here, we first review the environmental and genetic factors shaping CD39 expression. Second, we report CD39 functions in the T cell compartment, highlighting its role …
CD39/CD73/A2AR pathway and cancer immunotherapy
The CD39 /CD73/A2AR signaling pathway has been shown to be associated with poor cancer prognosis. In addition, CD39 and CD73 are also involved in the formation of new lymphatic …
Review immune response of targeting CD39 in cancer
2023年6月7日 · Targeting CD39 in cancer has been shown to not only decrease adenosine levels in the tumor microenvironment (TME), but also increase ATP levels. Additionally, targeting …
The ectonucleotidases CD39 and CD73 on T cells: The new pillar of ...
2023年1月26日 · CD39 is an extracellular enzyme known as ecto-nucleotide triphosphate diphosphohydrolase 1 (ENTPDase1), which belongs to the membrane-bound extracellular …
CD39 - AbbVie Science
The function of CD39 is to hydrolyze extracellular adenosine triphosphate (eATP) to adenosine monophosphate (AMP) by removing up to two phosphate groups. AMP can then be converted …
Role of TGF-β Signaling in Generation of CD39
2014年9月15日 · There is growing evidence that generation of adenosine from ATP, which is mediated by the CD39/CD73 enzyme pair, predetermines immunosuppressive and …
CD39 delineates chimeric antigen receptor regulatory T cell …
2024年6月13日 · CD39 is a membrane-bound protein marker of a Treg subset associated with increased suppressive capacity and phenotypic stability (13). CD39 converts extracellular ATP …
CD39 is an ectoenzyme (ecto-nucleotide triphosphate diphosphohydrolase 1, en-coded by ENTPD1 gene) belonging to the family of ectonucleotidases which comprises ecto-50 …
ENTPD1 Gene - GeneCards | ENTP1 Protein | ENTP1 Antibody
2024年10月2日 · ENTPD1 (Ectonucleoside Triphosphate Diphosphohydrolase 1) is a Protein Coding gene. Diseases associated with ENTPD1 include Spastic Paraplegia 64, Autosomal …