The Cyclin-dependent kinase 1: more than a cell cycle regulator
2023年10月28日 · CDK1, the first identified member of the Cdk family, is conserved in all organisms and regulates the transition between the G2 phase and mitosis. The activity of CDK1 is modulated by its...
Targeting CDK1 in cancer: mechanisms and implications
2023年6月13日 · Cyclin dependent kinases (CDKs) are serine/threonine kinases that are proposed as promising candidate targets for cancer treatment. These proteins complexed with cyclins play a critical role...
An overview of Cdk1-controlled targets and processes - Cell Division
2010年5月13日 · Approximately 75 targets of Cdk1 have been identified that control critical cell cycle events, such as DNA replication and segregation, transcriptional programs and cell morphogenesis.
Cyclin-dependent kinase 1 (Cdk1) is essential for cell division …
2012年2月21日 · Cyclin-dependent kinase 1 (Cdk1) is an archetypical kinase and a central regulator that drives cells through G2 phase and mitosis. Knockouts of Cdk2, Cdk3, Cdk4, or Cdk6 have resulted in viable mice, but the in vivo functions of Cdk1 have not …
CDK1: beyond cell cycle regulation - PMC - National Center for ...
2017年12月14日 · Cyclin-dependent kinase 1 (CDK1) has recently been shown to promote replicative DNA synthesis and may contribute to chemoresistance. These findings provide novel insights into coordination between cell cycle regulation and DNA replication in the maintenance of genomic stability.
Cell adhesion is regulated by CDK1 during the cell cycle - PMC
CDK1, in complex with cyclin A2, promotes adhesion complex and actin cytoskeleton organization during interphase and mediates a large increase in adhesion complex area as cells transition from G1 into S. Adhesion complex area decreases in G2, …
Core control principles of the eukaryotic cell cycle - Nature
2022年6月8日 · In the fission yeast, S-CDK consists of Cdk1 (encoded by cdc2) complexed with the S phase cyclin Cig2, and M-CDK consists of Cdk1 complexed with the M-cyclin Cdc13.
Cdk1 is sufficient to drive the mammalian cell cycle - PubMed
2007年8月16日 · These results indicate that Cdk1 is the only essential cell cycle Cdk. Moreover, they show that in the absence of interphase Cdks, Cdk1 can execute all the events that are required to drive cell division.
Cell Cycle-Dependent Transcription: The Cyclin Dependent Kinase Cdk1 …
2022年1月24日 · The cyclin-dependent kinase Cdk1 is best known for its function as master regulator of the cell cycle. It phosphorylates several key proteins to control progression through the different phases of the cell cycle.
Cyclin B1/CDK1-regulated mitochondrial bioenergetics in cell cycle ...
CDK1, among the well-defined cell cycle check point proteins, is involved in regulation of an array of fundamental cellular functions for cell proliferative growth [50, 51]. Mouse embryos lacking CDK2, CDK3, CDK4, and CDK6 are still able to undergo organogenesis whereas fail …
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