Redox-Active Selenium Compounds—From Toxicity and Cell …
2015年5月13日 · These redox active compounds are pro-oxidative and highly cytotoxic to tumor cells and are promising candidates to be used in chemotherapy against cancer. Herein we elaborate upon the major forms of dietary selenium compounds, their metabolic pathways, and their antioxidant and pro-oxidant potentials with emphasis on cytotoxic mechanisms.
Redox-Active Selenium Compounds—From Toxicity and Cell …
2015年5月13日 · One class of selenium compounds is a potent inhibitor of cell growth with remarkable tumor specificity. These redox active compounds are pro-oxidative and highly cytotoxic to tumor cells and are promising candidates to be used in chemotherapy against cancer.
Redox-active selenium compounds--from toxicity and cell …
2015年5月13日 · Herein we elaborate upon the major forms of dietary selenium compounds, their metabolic pathways, and their antioxidant and pro-oxidant potentials with emphasis on cytotoxic mechanisms. Relative cytotoxicity of inorganic selenite and organic selenocystine compounds to different cancer cells are presented as evidence to our perspective.
Selenocystine induces reactive oxygen species–mediated apoptosis …
2009年2月1日 · The thiol-reducing antioxidants, glutathione and N-acetylcysteine, inhibited intracellular ROS generation, DNA strand breaks and accumulation of sub-G1 population in MCF7 cells exposed to selenocystine. Our results suggest a possible role of ROS as a mediator of the signaling pathway of selenocystine-induced, DNA damage–mediated apoptosis in ...
Selenocystine induces reactive oxygen species-mediated …
In this study, selenocystine, a nutritionally available selenoamino acid, was identified as a novel agent with broad-spectrum antitumor activity. A panel of eight human cancer cell lines was shown to be susceptible to selenocystine, with IC(50) values ranging from 3.6 to 37.0 microM.
The antioxidant role of selenium and seleno-compounds
2003年5月1日 · Selenite-induced cytotoxicity and apoptosis in human carcinoma cells can be inhibited with copper (CuSO 4) as an antioxidant. High doses of selenite result in induction of 8-hydroxydeoxyguanosine (8-OHdG) in mouse skin cell DNA and in primary human keratinocytes.
A micronutrient with major effects on cancer cell viability
2020年7月6日 · In this issue, Carlisle et al. describe a novel mechanism whereby perturbing selenium utilization via inhibition of SEPHS2, a component of the selenocysteine-biosynthesis pathway, results in...
(PDF) Redox-Active Selenium Compounds—From Toxicity and Cell …
2015年5月5日 · One class of selenium compounds is a potent inhibitor of cell growth with remarkable tumor specificity. These redox active compounds are pro-oxidative and highly cytotoxic to tumor cells and...
Extracellular thiol-assisted selenium uptake dependent on the xc− ...
2009年7月7日 · Our data show that selenium uptake and accumulation, rather than intracellular events, are crucial to the specific selenite cytotoxicity observed in resistant cancer cells. We show that selenium uptake depends on extracellular reduction, and that the extracellular environment is a key factor specific to selenite cytotoxicity.
[PDF] Redox-Active Selenium Compounds—From Toxicity and Cell …
2015年5月1日 · Herein we elaborate upon the major forms of dietary selenium compounds, their metabolic pathways, and their antioxidant and pro-oxidant potentials with emphasis on cytotoxic mechanisms. Relative cytotoxicity of inorganic selenite and organic selenocystine compounds to different cancer cells are presented as evidence to our perspective.