CGRP sensory neurons promote tissue healing via neutrophils and ...
2024年3月27日 · CGRP acts via receptor activity-modifying protein 1 (RAMP1) on neutrophils, monocytes and macrophages to inhibit recruitment, accelerate death, enhance efferocytosis and polarize macrophages...
CGRP, a neurotransmitter of enteric sensory neurons ... - PubMed
In the present study, a CGRP-receptor antagonist BIBN4096BS significantly alleviated allergic symptoms in the murine FA model. In addition, the elevated numbers of mucosal mast cells in the proximal colon of FA mice were significantly decreased in that of BIBN4096BS-treated FA mice.
Trigeminal ganglion neurons are directly activated by influx of CSF ...
2024年7月4日 · CSF collected from animals exposed to CSD activates trigeminal neurons in naïve mice in part by CSF-borne calcitonin gene–related peptide (CGRP). We identify a communication pathway between the central and peripheral nervous system that might explain the relationship between migrainous aura and headache.
Encoding of danger by parabrachial CGRP neurons | Nature
2018年3月21日 · Neurons that express calcitonin gene-related peptide in the parabrachial nucleus (CGRP PBN neurons) relay sensory signals that contribute to satiation and pain-induced fear behaviour, but it is...
Nociceptor neurons direct goblet cells via a CGRP-RAMP1 ... - Cell …
2022年10月14日 · Capsaicin triggered robust DRG neuron activation and CGRP release in vitro (Figures 3E–3J). Oral gavage of capsaicin also dramatically induced increased colonic mucus thickness (Figures 3M and 3N). These results indicate that nociceptors can directly sense intestinal commensal cues and capsaicin to release CGRP.
The Parabrachial Nucleus: CGRP Neurons Function as a General …
2018年5月1日 · CGRP PBN neurons relay a wide variety of aversive signals (e.g., food poisoning, pain, itch, and hypercapnia) to the central nucleus of the amygdala, the bed nucleus of the stria terminalis, and other brain regions. Activation of CGRP PBN neurons is necessary and sufficient to establish robust foot-shock and taste memories.
Peripheral and central innervation pattern of mechanosensory …
1 天前 · Primary antibodies used for immunofluorescent staining were anti-CGRP (rabbit, 1:500, Immunostar, 24112), anti-NFH (chicken, 1:500, Aves lab, NFH), anti-Dsred (rabbit, Clontech, 632496), anti-NeuN (Guinea Pig, 1:500, Millipore, ABN90). ... In the mechanical sneezing model induced by starch or pepper, mice were restrained to breathe in the ...
Sensory neurons increase keratinocyte proliferation through CGRP ...
2024年7月1日 · We showed that sensory neurons can participate directly to keratinocyte hyperproliferation in the formation of psoriatic lesions through the release of CGRP, independently of the immune system.
Pathways of CGRP Release from Primary Sensory Neurons
The benefit reported in a variety of clinical trials by a series of small molecule antagonists for the calcitonin gene-related peptide (CGRP) receptor, or four monoclonal antibodies against the neuropeptide or its receptor, has underscored the release of CGRP from terminals of primary sensory neuron …
Neuromuscular Junction Morphology and Gene Dysregulation in …
In the wobbler mouse model of ALS, we have identified CGRP as a potential factor in the progression of motor neuron degeneration, acting at the neuromuscular junction. We have shown an increase in CGRP mRNA expression in the wobbler spinal cord, concurrent with an increase in CALCRL protein expression in the bicep.